ArticleScientific reports2018
Early-onset liver cancer in South America associates with low hepatitis B virus DNA burden.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Cognitive changes associated with chemotherapy in breast cancer: an assessment of social cognition and executive functions in Peruvian patients.The oncologist · 2026Article
- Mapping pesticide mixtures to cancer risk at the country scale with spatial exposomics.Nature health · 2026Article
- Liver Cancer Mortality Rates in Peru: Trend Analysis from 2003 to 2017.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Geographic diversity of human liver cancers mirrors global social inequalities.Frontiers in oncology · 2025Review
- Clinical Characteristics and Prognosis of Early-Onset Hepatocellular Carcinoma: A Retrospective Cohort Study Based on Population Data.Digestive diseases and sciences · 2024Article
- Comparison of metastasis and prognosis between early-onset and late-onset hepatocellular carcinoma: A population-based study.Heliyon · 2024Article
- Review
- Viral Kinetics of an Acute Hepatitis B Virus Subgenotype F1b Infection in a Mexican Subject.Clinical liver disease · 2022Article
- Sexual Dimorphism in Chronic Hepatitis B Virus (HBV) Infection: Evidence to Inform Elimination Efforts.Wellcome open research · 2022Review
- Metallomic profile in non-cirrhotic hepatocellular carcinoma supports a phenomenon of metal metabolism adaptation in tumor cells.Scientific reports · 2021Article
- Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry.Oncotarget · 2021Article
- Extending treatment eligibility for chronic hepatitis B virus infection.Nature reviews. Gastroenterology & hepatology · 2021Article
- Biological Characterization of Hepatitis B virus Genotypes: Their Role in Viral Replication and Antigen Expression.Frontiers in microbiology · 2021Article
- Hepatitis B-related hepatocellular carcinoma: surveillance strategy directed by immune-epidemiology.Hepatoma research · 2021Article
- Quantitative analysis of the splice variants expressed by the major hepatitis B virus genotypes.Microbial genomics · 2021Article
- Droplet digital PCR detects high rate of TP53 R249S mutants in cell-free DNA of middle African patients with hepatocellular carcinoma.Clinical and experimental medicine · 2018Article
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10 authors.
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Abstract
In Peru, hepatocellular carcinoma (HCC) arises in young non-cirrhotic patients. Hepatitis B virus (HBV) is suspected to be the prominent etiological agent. We thus performed a comprehensive molecular study of HBV infection in 65 Peruvian HCC patients. Only 51% were considered as persistently infected at the onset. HBV DNA was found by PCR in the tumor and/or matched non-tumor liver tissues in more than 80% of cases (n = 53/65). HBV DNA was significantly more abundant in livers of younger patients than in those of the older ones. We consistently observed low viral DNA burden (0.1-6.5 copies for 100 cells), with viral genomes in younger patients displaying higher proportion of mutations at di-pyrimidines (TpT and CpC, P = 0.006). A drastic activation of multiple DNA repair pathways in tumors of younger patients was observed. Our observations clearly challenge the current vision that associates high HBV DNA load with earlier tumor development. We concluded that in Peru, and maybe in other populations with Americas' indigenous ancestry, HBV-associated liver tumorigenesis might differ significantly from that generally observed in the rest of the world. Procedures used to screen for HCC development in subjects at risk should be adapted to the local situation.
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