ArticleScientific reports2018
Comparative toxicity of synchrotron and conventional radiation therapy based on total and partial body irradiation in a murine model.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
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Who cites it
66 citing papers in PubMed.
- X‑ray FLASH RT inhibits lung cancer bone metastasis via activating CD4⁺ T-cell‑mediated antitumor immunity with modulation of Th17 cell response.Oncoimmunology · 2026Article
- TOPAS-nBio simulation of the impact of ultrahigh dose rate and oxygen concentration on the Fenton reaction using the Fricke solution.Medical physics · 2026Article
- Harnessing the sparing effect of FLASH-RT: From phenomenon observation, radiophysical determinants to molecular mechanisms and synergistic strategies.Materials today. Bio · 2026Review
- Development and evaluation of an in vivo dose-based monitoring system for electron FLASH radiation therapy.Medical physics · 2026Article
- The Use of Synchrotron Radiation in the Medical Sciences.Photon science · 2026Article
- FLASH radiotherapy as an emerging paradigm in radioimmunotherapy: biological rationale, preclinical evidence, and translational roadmap.Frontiers in immunology · 2026Review
- Quantifying the flash effect and its dependence on average dose rate in vivo for 6 MeV electron and 6 MV photon beams.Clinical and translational radiation oncology · 2026Article
- Partial abdominal carbon-ion FLASH irradiation spares lethality compared to conventional irradiation: impact of LET and dose rate.Radiation oncology (London, England) · 2025Article
- Factors Influencing the Biological Effects of FLASH Irradiation.Antioxidants (Basel, Switzerland) · 2025Review
- Effects and potential mechanisms of the ultra-high dose rate radiotherapy on lung injury: a review.Radiation oncology (London, England) · 2025Review
- Application of Synchrotron Radiation in Fundamental Research and Clinical Medicine.Biomedicines · 2025Review
- Ultra‑high dose rate (FLASH) treatment: A novel radiotherapy modality (Review).Molecular and clinical oncology · 2025Review
- Instantaneous dose rate as a crucial factor in reducing mortality and normal tissue toxicities in murine total-body irradiation: a comparative study of dose rate combinations.Molecular medicine (Cambridge, Mass.) · 2025Article
- Whole Abdominal Pencil Beam Scanned Proton FLASH Increases Acute Lethality.International journal of radiation oncology, biology, physics · 2025Article
- Superior Anti-Tumor Response After Microbeam and Minibeam Radiation Therapy in a Lung Cancer Mouse Model.Cancers · 2025Article
- Respiratory-gated micro-computed tomography imaging to measure radiation-induced lung injuries in mice following ultra-high dose-rate and conventional dose-rate radiation therapy.Journal of medical imaging (Bellingham, Wash.) · 2025Article
- Proton minibeam radiotherapy: a review.Frontiers in oncology · 2025Review
- The influence of beam parameters on FLASH effect.Frontiers in oncology · 2025Review
- The Impact of Synchrotron Microbeam Radiation Therapy Combined With Broad Beam in a Preclinical Breast Cancer Model.Advances in radiation oncology · 2025Article
- Development of novel ionization chambers for reference dosimetry in electron flash radiotherapy.Medical physics · 2024Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synchrotron radiation can facilitate novel radiation therapy modalities such as microbeam radiation therapy (MRT) and high dose-rate synchrotron broad-beam radiation therapy (SBBR). Both of these modalities have unique physical properties that could be exploited for an improved therapeutic effect. While pre-clinical studies report promising normal tissue sparing phenomena, systematic toxicity data are still required. Our objective was to characterise the toxicity of SBBR and MRT and to calculate equivalent doses of conventional radiation therapy (CRT). A dose-escalation study was performed on C57BLJ/6 mice using total body and partial body irradiations. Dose-response curves and TD
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.