ArticleNature immunology2018
IgG3 regulates tissue-like memory B cells in HIV-infected individuals.
Article in Nature immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 35 citations in OpenAlex.
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- Multifaceted B cell response to transient HIV viremia in elite controllers.PLoS pathogens · 2026Article
- SARS-CoV-2 infection and vaccination elicit distinct pharyngeal mucosal B cell responses in children.Research square · 2025Article
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- Immunogenicity of COVID-19 vaccines and their effect on HIV reservoir in older people with HIV.iScience · 2023Article
- Immunogenicity of COVID-19 vaccines and their effect on the HIV reservoir in older people with HIV.bioRxiv : the preprint server for biology · 2023Article
- Metabolomics meets systems immunology.EMBO reports · 2023Review
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- Recent SARS-CoV-2 infection abrogates antibody and B-cell responses to booster vaccination.medRxiv : the preprint server for health sciences · 2022Article
- Adaptive immune cell responses as therapeutic targets in antibody-mediated organ rejection.Trends in molecular medicine · 2022Review
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- B-Cell Responses to Sars-Cov-2 mRNA Vaccines.Pathogens & immunity · 2022Review
- T-bet+CD27+CD21- B cells poised for plasma cell differentiation during antibody-mediated rejection of kidney transplants.JCI insight · 2021Article
- Human antiviral B cell responses: Emerging lessons from hepatitis B and COVID-19.Immunological reviews · 2021Review
- Rapid Emergence of T Follicular Helper and Germinal Center B Cells Following Antiretroviral Therapy in Advanced HIV Disease.Frontiers in immunology · 2021Article
- Expression of inhibitory receptors by B cells in chronic human infectious diseases restricts responses to membrane-associated antigens.Science advances · 2020Article
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Authors and funding
18 authors at 3 institutions in 1 country.
Funding
Abstract
Immunoglobulin G3 (IgG3) has an uncertain role in the response to infection with and vaccination against human immunodeficiency virus (HIV). Here we describe a regulatory role for IgG3 in dampening the immune system-activating effects of chronic HIV viremia on B cells. Secreted IgG3 was bound to IgM-expressing B cells in vivo in HIV-infected chronically viremic individuals but not in early-viremic or aviremic individuals. Tissue-like memory (TLM) B cells, a population expanded by persistent HIV viremia, bound large amounts of IgG3. IgG3 induced clustering of B cell antigen receptors (BCRs) on the IgM
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.