ArticleNature nanotechnology2018
Plasmonic meta-electrodes allow intracellular recordings at network level on high-density CMOS-multi-electrode arrays.
Article in Nature nanotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 47 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 99 citations in OpenAlex.
- Vertically Aligned Nanopillar Electrodes: Engineered Interfaces for Electrophysiology and Cell-Electrode Coupling.Small methods · 2026Review
- Low-dimensional materials for intracellular electrophysiology: advances from synthesis to applications.Microsystems & nanoengineering · 2026Review
- Morphology-modified contributions of electronic transitions to the optical response of plasmonic nanoporous gold metamaterial.Nature communications · 2026Article
- Artificial intelligence-enabled "inherited noninvasive intracellular recording" for prolonged monitoring of cardiac action potentials.Science advances · 2026Article
- Nongenetic Photostimulation of hiPSC Neurons Using Plasmonic Nanopyramids.ACS photonics · 2025Article
- Advances in large-scale electrophysiology with high-density microelectrode arrays.Lab on a chip · 2025Review
- Non-invasive action potential recordings using printed electrolyte-gated polymer field-effect transistors.Nature communications · 2025Article
- Cellular Signal Detection by Hydrogenated Amorphous Silicon Photosensitive Chip with Electroexcitation.Sensors (Basel, Switzerland) · 2025Article
- Planar-electroporated cell biosensor for investigating potential therapeutic effects of ectopic bitter receptors.Microsystems & nanoengineering · 2025Article
- Silicon Nanowire Mats Enable Advanced Bioelectrical Recordings in Primary DRG Cell Cultures.Advanced healthcare materials · 2025Article
- Materials and device strategies to enhance spatiotemporal resolution in bioelectronics.Nature reviews. Materials · 2025Article
- Advanced passive 3D bioelectronics: powerful tool for the cardiac electrophysiology investigation.Microsystems & nanoengineering · 2025Review
- Multi-material Electrohydrodynamic Printing of Bioelectronics with Sub-Microscale 3D Gold Pillars for In Vitro Extra- and Intra-Cellular Electrophysiological Recordings.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Longitudinal and Noninvasive Intracellular Recordings of Spontaneous Electrophysiological Activity in Rat Primary Neurons on Planar MEA Electrodes.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Microfluidic platforms for monitoring cardiomyocyte electromechanical activity.Microsystems & nanoengineering · 2025Review
- Article
- Inspiring a convergent engineering approach to measure and model the tissue microenvironment.Heliyon · 2024Review
- Active Micro-Nano-Collaborative Bioelectronic Device for Advanced Electrophysiological Recording.Nano-micro letters · 2024Review
- Nanotechnology and Cancer Bioelectricity: Bridging the Gap Between Biology and Translational Medicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- A snapshot review on materials enabled multimodal bioelectronics for neurological and cardiac research.MRS advances · 2023Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to monitor electrogenic cells accurately plays a pivotal role in neuroscience, cardiology and cell biology. Despite pioneering research and long-lasting efforts, the existing methods for intracellular recording of action potentials on the large network scale suffer limitations that prevent their widespread use. Here, we introduce the concept of a meta-electrode, a planar porous electrode that mimics the optical and biological behaviour of three-dimensional plasmonic antennas but also preserves the ability to work as an electrode. Its synergistic combination with plasmonic optoacoustic poration allows commercial complementary metal-oxide semiconductor multi-electrode arrays to record intracellular action potentials in large cellular networks. We apply this approach to measure signals from human-induced pluripotent stem cell-derived cardiac cells, rodent primary cardiomyocytes and immortalized cell types and demonstrate the possibility of non-invasively testing a variety of relevant drugs. Due to its robustness and easiness of use, we expect the method will be rapidly adopted by the scientific community and by pharmaceutical companies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.