Evidence map›Paper›PMID 30104615›Full record

ReviewNature reviews. Urology2018

Pelvic lymph node dissection during radical cystectomy for muscle-invasive bladder cancer.

Marlon Perera, Shannon McGrath, Shomik Sengupta, Jack Crozier, Damien Bolton, Nathan Lawrentschuk

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05123625 (A Phase III Randomized Non-inferiority Multicenter Study of PLND Omission in Clinical NMIBC Undergoing Radical Cystectomy), which is not on this map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05123625 narecruitingnot on this mapstarted 2021, after this paper: background citation

A Phase III Randomized Non-inferiority Multicenter Study of PLND Omission in Clinical NMIBC Undergoing Radical Cystectomy

TypeinterventionalSponsorThe First Affiliated Hospital with Nanjing Medical UniversityRan2021 to 2028Enrolled200ConditionsBladder CancerArmsReduce surgical procedures
3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.

  1. Pooled it
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  14. [European journal of nuclear medicine and molecular imaging · 2024
    Article
  15. Comparative real-world survival outcomes of muscle-invasive bladder cancer treated with bladder-only vs. whole-pelvis concurrent chemoradiation.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Marlon PereraDepartment of Surgery, Austin Health, University of Melbourne, Melbourne, Victoria, Australia. marlonlperera@gmail.com.
Shannon McGrathDepartment of Surgery, Austin Health, University of Melbourne, Melbourne, Victoria, Australia.
Shomik SenguptaDepartment of Surgery, Austin Health, University of Melbourne, Melbourne, Victoria, Australia.
Jack CrozierDepartment of Surgery, Austin Health, University of Melbourne, Melbourne, Victoria, Australia.
Damien BoltonDepartment of Surgery, Austin Health, University of Melbourne, Melbourne, Victoria, Australia.
Nathan LawrentschukDepartment of Surgery, Austin Health, University of Melbourne, Melbourne, Victoria, Australia.
University of Melbourne · AUAustin Health · AUOlivia Newton-John Cancer Wellness & Research Centre · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radical cystectomy is the gold-standard treatment option for muscle-invasive and metastatic bladder cancer. At the time of cystectomy, up to 25% of patients harbour metastatic lymph node deposits. These deposits most frequently occur in the obturator fossa, but can be as proximal as the interaortocaval region. Thus, the use of concurrent pelvic lymph node dissection (PLND) with cystectomy has been increasingly reported. Data from studies including many patients suggest substantial oncological benefit in PLND cohorts versus non-PLND cohorts, irrespective of pathological nodal status. Additionally, PLND provides useful prognostic information, including disease burden, lymph node density, and extracapsular extension of metastatic lymph nodes. Accordingly, the National Comprehensive Cancer Network guidelines advocate the use of PLND during radical cystectomy for muscle-invasive bladder cancer. Despite this recommendation, a lack of consensus exists regarding the optimal PLND template. Comparative series suggest that extended PLND provides improved recurrence-free survival and cancer-specific survival compared with more limited PLND templates. More extensive templates (such as super-extended PLND) provide no additional survival benefit at the potential cost of increased operative time and patient morbidity. In addition to extended PLND templates, increased nodal harvest confers an oncological benefit in patients with node-positive disease or in patients with node-negative disease. Accordingly, recommendations for a minimum nodal yield have been proposed. Despite the growing body of evidence, formal recommendations by oncological and urological authoritative bodies have been limited owing to the lack of randomized data and level I evidence.

Indexed as

Carcinoma, Transitional CellCystectomyHumansLymphatic MetastasisLymph Node ExcisionPelvisUrinary Bladder Neoplasms

Identifiers

PMID30104615
OpenAlexW2885554167

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.