Evidence map›Paper›PMID 30104604›Full record

ArticleScientific reports2018

Snake Venom Extracellular vesicles (SVEVs) reveal wide molecular and functional proteome diversity.

Victor Corassolla Carregari, Livia Rosa-Fernandes, Paulo Baldasso, Sergio Paulo Bydlowski, Sergio Marangoni, Martin R Larsen, Giuseppe Palmisano

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Extracellular Vesicles in Veterinary Medicine.Animals : an open access journal from MDPI · 2022
    Review
  10. SialylatedJournal of extracellular biology · 2022
    Article
  11. Review
  12. Linking toxicity and predation in a venomous arthropod: the case ofThe journal of venomous animals and toxins including tropical diseases · 2022
    Article
  13. Article
  14. Article
  15. Article
  16. In-depth transcriptome reveals the potential biotechnological application ofThe journal of venomous animals and toxins including tropical diseases · 2020
    Article
  17. Recombinant antibodies against Iranian cobra venom as a new emerging therapy by phage display technology.The journal of venomous animals and toxins including tropical diseases · 2020
    Article
  18. Review
  19. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Victor Corassolla CarregariDepartment of Biochemistry, Institute of Biology (IB), Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil.
Livia Rosa-FernandesGlycoProteomics Laboratory, Department of Parasitology, ICB, University of São Paulo, São Paulo, Brazil.ORCID 0000-0003-1612-1950
Paulo BaldassoDepartment of Biochemistry, Institute of Biology (IB), Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil.
Sergio Paulo BydlowskiLaboratory of Genetics and Molecular Hematology (LIM31), University of São Paulo Medical School (FMUSP), São Paulo, Brazil.
Sergio MarangoniDepartment of Biochemistry, Institute of Biology (IB), Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil.
Martin R LarsenDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
Giuseppe PalmisanoGlycoProteomics Laboratory, Department of Parasitology, ICB, University of São Paulo, São Paulo, Brazil. palmisano.gp@usp.br.
Universidade de São Paulo · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proteins constitute almost 95% of snake venom's dry weight and are produced and released by venom glands in a solubilized form during a snake bite. These proteins are responsible for inducing several pharmacological effects aiming to immobilize and initiate the pre-digestion of the prey. This study shows that proteins can be secreted and confined in snake venom extracellular vesicles (SVEVs) presenting a size distribution between 50 nm and 500 nm. SVEVs isolated from lyophilized venoms collected from four different species of snakes (Agkistrodon contortrix contortrix, Crotalus atrox, Crotalus viridis and Crotalus cerberus oreganus) were analyzed by mass spectrometry-based proteomic, which allowed the identification of proteins belonging to eight main functional protein classes such as SVMPs, serine proteinases, PLA

Indexed as

AgkistrodonAnimalsCell SurvivalChromatography, High Pressure LiquidCrotalid VenomsCrotalusExtracellular VesiclesFibrinogenHumansHuman Umbilical Vein Endothelial CellsMass SpectrometryProteomeProteomicsReptilian ProteinsToxicity TestsCrotalid VenomsFibrinogenProteomeReptilian Proteins

Identifiers

PMID30104604
PMCPMC6089973
OpenAlexW2887395406

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.