Evidence map›Paper›PMID 30104563›Full record

ArticleNature communications2018

Single-molecule detection with a millimetre-sized transistor.

Eleonora Macchia, Kyriaki Manoli, Brigitte Holzer, Cinzia Di Franco, Matteo Ghittorelli, Fabrizio Torricelli, Domenico Alberga, Giuseppe Felice Mangiatordi, Gerardo Palazzo, Gaetano Scamarcio and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Chemical science · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Plasmonic Single-Molecule Affinity Detection at 10Advanced materials (Deerfield Beach, Fla.) · 2025
    Article
  15. Electric Field Cycling of Physisorbed Antibodies Reduces Biolayer Polarization Dispersion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Eleonora MacchiaDipartimento di Chimica, Università degli Studi di Bari "Aldo Moro", 70125 Bari, Italy.
Kyriaki ManoliDipartimento di Chimica, Università degli Studi di Bari "Aldo Moro", 70125 Bari, Italy.ORCID http://orcid.org/0000-0002-7600-0977
Brigitte HolzerDipartimento di Chimica, Università degli Studi di Bari "Aldo Moro", 70125 Bari, Italy.ORCID http://orcid.org/0000-0003-4400-9827
Cinzia Di FrancoCNR, Istituto di Fotonica e Nanotecnologie, Sede di Bari, 70125 Bari, Italy.
Matteo GhittorelliDipartimento Ingegneria dell'Informazione, Università degli Studi di Brescia, 25123 Brescia, Italy.ORCID http://orcid.org/0000-0002-2224-5063
Fabrizio TorricelliDipartimento Ingegneria dell'Informazione, Università degli Studi di Brescia, 25123 Brescia, Italy.ORCID http://orcid.org/0000-0002-7932-0677
Domenico AlbergaDipartimento di Farmacia, Scienze del Farmaco, Università degli Studi di Bari "Aldo Moro", 70125 Bari, Italy.
Giuseppe Felice MangiatordiDipartimento di Farmacia, Scienze del Farmaco, Università degli Studi di Bari "Aldo Moro", 70125 Bari, Italy.
Gerardo PalazzoDipartimento di Chimica, Università degli Studi di Bari "Aldo Moro", 70125 Bari, Italy.ORCID http://orcid.org/0000-0001-5504-2177
Gaetano ScamarcioCNR, Istituto di Fotonica e Nanotecnologie, Sede di Bari, 70125 Bari, Italy.ORCID http://orcid.org/0000-0003-0808-4336
Luisa TorsiDipartimento di Chimica, Università degli Studi di Bari "Aldo Moro", 70125 Bari, Italy. luisa.torsi@uniba.it.ORCID http://orcid.org/0000-0002-0798-0780

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Label-free single-molecule detection has been achieved so far by funnelling a large number of ligands into a sequence of single-binding events with few recognition elements host on nanometric transducers. Such approaches are inherently unable to sense a cue in a bulk milieu. Conceptualizing cells' ability to sense at the physical limit by means of highly-packed recognition elements, a millimetric sized field-effect-transistor is used to detect a single molecule. To this end, the gate is bio-functionalized with a self-assembled-monolayer of 10

Indexed as

Single Molecule ImagingTransistors, ElectronicAnimalsBlood ProteinsCattleElectrolytesFemaleHumansStaining and LabelingBlood ProteinsElectrolytes

Identifiers

PMID30104563
PMCPMC6089965

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.