Evidence map›Paper›PMID 30104547›Full record

ArticleInternational journal of molecular sciences2018

Novel Therapeutic Agent against Platelet Activation In Vitro and Arterial Thrombosis In Vivo by Morin Hydrate.

Chih-Wei Hsia, Ming-Ping Wu, Marappan Velusamy, Chih-Hsuan Hsia, Duen-Suey Chou, Cheng-Lin Tsai, Chia-Yuan Hsu, Thanasekaran Jayakumar, Chi-Li Chung, Joen-Rong Sheu

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Plant Natural Products for Human Health.International journal of molecular sciences · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Chih-Wei HsiaGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. d119106003@tmu.edu.tw.
Ming-Ping WuGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. mpwu@mail.chimei.org.tw.
Marappan VelusamyDepartment of Chemistry, North Eastern Hill University, Shillong 793022, India. mvelusamy@gmail.com.
Chih-Hsuan HsiaGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. d119102013@tmu.edu.tw.
Duen-Suey ChouDepartment of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. fird@tmu.edu.tw.
Cheng-Lin TsaiGraduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taipei 110, Taiwan. ma48106001@tmu.edu.tw.ORCID 0000-0001-5551-4410
Chia-Yuan HsuGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. gordanmike1003@gmail.com.
Thanasekaran JayakumarGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. tjaya_2002@yahoo.co.in.
Chi-Li ChungDivision of Pulmonary Medicine, Department of Internal Medical, Taipei Medical University Hospital, Taipei 110, Taiwan. clchung@tmu.edu.tw.
Joen-Rong SheuGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. sheujr@tmu.edu.tw.
Taipei Medical University · TWChi Mei Medical Center · TWNorth Eastern Hill University · INTaipei Medical University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Morin hydrate, a bioactive flavonoid, has been proven to prevent inflammation and apoptosis of cells. Flavonoids can reduce the risk of cardiovascular diseases, in which platelet activation plays a major role. This study investigated the effect of morin hydrate on platelet activation in vitro and in vivo. Morin hydrate markedly inhibited platelet aggregation stimulated by collagen in human platelets but not that stimulated by other agonists. In collagen-activated platelets, morin hydrate inhibited adenosine triphosphate (ATP) release; intracellular Ca

Indexed as

Adenosine TriphosphateAnimalsBlood PlateletsCalciumFlavonesFlavonoidsHumansMaleMiceMice, Inbred ICRMitogen-Activated Protein KinasesPlatelet ActivationPlatelet AggregationProtein Kinase CProto-Oncogene Proteins c-aktP-SelectinAdenosine TriphosphateCalciumFlavonesFlavonoidsMitogen-Activated Protein KinasesmorinProtein Kinase CProto-Oncogene Proteins c-aktP-Selectinbleeding timeflavonoidmorin hydrateOH· free radicalplatelet activationprotein kinasethromboembolism

Identifiers

PMID30104547
PMCPMC6121409
OpenAlexW2885937660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.