Evidence map›Paper›PMID 30104363›Full record

Trial reportProceedings of the National Academy of Sciences of the United States of America2018

Recurrent computations for visual pattern completion.

Hanlin Tang, Martin Schrimpf, William Lotter, Charlotte Moerman, Ana Paredes, Josue Ortega Caro, Walter Hardesty, David Cox, Gabriel Kreiman

Open access · bronzeAbstract readClinical Trial
In one paragraph

Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 239 citations in OpenAlex.

  1. Article
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  5. Ecological Visual Processing in the Mouse.Annual review of neuroscience · 2026
    Review
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  13. Effects of Partial Occlusion on Response Dynamics and Interregional Processing within Primate Superior Temporal Sulcus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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  19. Neural Dynamics in Extrastriate Cortex Underlying False Alarms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  20. Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Hanlin TangProgram in Biophysics, Harvard University, Boston, MA 02115.
Martin SchrimpfChildren's Hospital, Harvard Medical School, Boston, MA 02115.
William LotterProgram in Biophysics, Harvard University, Boston, MA 02115.
Charlotte MoermanChildren's Hospital, Harvard Medical School, Boston, MA 02115.
Ana ParedesChildren's Hospital, Harvard Medical School, Boston, MA 02115.
Josue Ortega CaroChildren's Hospital, Harvard Medical School, Boston, MA 02115.
Walter HardestyChildren's Hospital, Harvard Medical School, Boston, MA 02115.
David CoxMolecular and Cellular Biology, Harvard University, Cambridge, MA 02138.
Gabriel KreimanChildren's Hospital, Harvard Medical School, Boston, MA 02115; gabriel.kreiman@tch.harvard.edu.ORCID 0000-0003-3505-8475
Boston Children's Hospital · USHarvard University · US

Funding

MOLECULAR BIOPHYSICS TRAINING GRANTT32GM008313 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MURTHY, VENKATESH N · 1989 to 2023
$14.6M
Neural dynamics underlying spatiotemporal cognitive integrationR01EY026025 · NEI · BOSTON CHILDREN'S HOSPITAL · PI KREIMAN, GABRIEL · 2016 to 2024
$3.7M
NEI NIH HHS R01 EY026025NIGMS NIH HHS T32 GM008313
6 · The paper itself

Abstract

Making inferences from partial information constitutes a critical aspect of cognition. During visual perception, pattern completion enables recognition of poorly visible or occluded objects. We combined psychophysics, physiology, and computational models to test the hypothesis that pattern completion is implemented by recurrent computations and present three pieces of evidence that are consistent with this hypothesis. First, subjects robustly recognized objects even when they were rendered <15% visible, but recognition was largely impaired when processing was interrupted by backward masking. Second, invasive physiological responses along the human ventral cortex exhibited visually selective responses to partially visible objects that were delayed compared with whole objects, suggesting the need for additional computations. These physiological delays were correlated with the effects of backward masking. Third, state-of-the-art feed-forward computational architectures were not robust to partial visibility. However, recognition performance was recovered when the model was augmented with attractor-based recurrent connectivity. The recurrent model was able to predict which images of heavily occluded objects were easier or harder for humans to recognize, could capture the effect of introducing a backward mask on recognition behavior, and was consistent with the physiological delays along the human ventral visual stream. These results provide a strong argument of plausibility for the role of recurrent computations in making visual inferences from partial information.

Indexed as

Computer SimulationModels, NeurologicalAdolescentAdultFemaleHumansMalePattern Recognition, Visualartificial intelligencecomputational neurosciencemachine learningpattern completionvisual object recognition

Identifiers

PMID30104363
PMCPMC6126774
OpenAlexW2623160143

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.