Evidence map›Paper›PMID 30104362›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Vegfaa instructs cardiac muscle hyperplasia in adult zebrafish.

Ravi Karra, Matthew J Foglia, Wen-Yee Choi, Christine Belliveau, Paige DeBenedittis, Kenneth D Poss

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.

  1. Pooled it
  2. Signaling pathways regulating cardiac regeneration.Cell regeneration (London, England) · 2026
    Review
  3. Article
  4. Article
  5. A Hypoxia-reoxygenation Injury Model in Self-assembling Human Cardioids.Journal of visualized experiments : JoVE · 2026
    Article
  6. Mechanisms and Therapeutic Potential of Human Cardiomyocyte Proliferation.Journal of cardiovascular development and disease · 2026
    Review
  7. Article
  8. Article
  9. Biomedicines · 2025
    Article
  10. Article
  11. Article
  12. Review
  13. Rewinding the clock: mechanisms of dedifferentiation.Current opinion in genetics & development · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ravi KarraDepartment of Medicine, Duke University Medical Center, Durham, NC 27710; ravi.karra@duke.edu kenneth.poss@duke.edu.
Matthew J FogliaRegeneration Next, Duke University, Durham, NC 27110.
Wen-Yee ChoiRegeneration Next, Duke University, Durham, NC 27110.
Christine BelliveauDepartment of Medicine, Duke University Medical Center, Durham, NC 27710.
Paige DeBenedittisDepartment of Medicine, Duke University Medical Center, Durham, NC 27710.
Kenneth D PossRegeneration Next, Duke University, Durham, NC 27110; ravi.karra@duke.edu kenneth.poss@duke.edu.
Duke University Hospital · USDuke Medical Center · USDuke University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
Regulation of Myocardial Regeneration in ZebrafishR01HL081674 · NHLBI · DUKE UNIVERSITY · PI POSS, KENNETH D · 2005 to 2019
$6.6M
Regulation of the Epicardial Injury Response During Heart Regeneration in ZebrafishR01HL131319 · NHLBI · DUKE UNIVERSITY · PI POSS, KENNETH D · 2016 to 2019
$1.6M
Biomarkers of Heart RegenerationK08HL116485 · NHLBI · DUKE UNIVERSITY · PI KARRA, RAVI · 2013 to 2017
$665k
Vegf Signaling and Cardiac Chamber Morphogenesis in ZebrafishF30HL126487 · NHLBI · DUKE UNIVERSITY · PI FOGLIA, MATTHEW J · 2015 to 2016
$68k
NHLBI NIH HHS F30 HL126487NHLBI NIH HHS K08 HL116485NHLBI NIH HHS R01 HL081674NHLBI NIH HHS R01 HL131319NIGMS NIH HHS T32 GM007171
6 · The paper itself

Abstract

During heart development and regeneration, coronary vascularization is tightly coupled with cardiac growth. Although inhibiting vascularization causes defects in the innate regenerative response of zebrafish to heart injury, angiogenic signals are not known to be sufficient for triggering regeneration events. Here, by using a transgenic reporter strain, we found that regulatory sequences of the angiogenic factor

Indexed as

AnimalsCardiomegalyEpithelial-Mesenchymal TransitionHyperplasiaMyocardiumMyocytes, CardiacVascular Endothelial Growth Factor AZebrafishZebrafish ProteinsVascular Endothelial Growth Factor AZebrafish Proteinsangiogenesisheartregenerationvegfa

Identifiers

PMID30104362
PMCPMC6126768
OpenAlexW2887155754

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.