ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
S-Nitrosylation of Divalent Metal Transporter 1 Enhances Iron Uptake to Mediate Loss of Dopaminergic Neurons and Motoric Deficit.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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0cells of the map it votes in
19citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
What it found
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- An Overview of the Role of Medicinal Plants in Parkinson's Disease: A Semi-Systematic Review.Biomedicines · 2025Review
- The Roles of DMT1 in Inflammatory and Degenerative Diseases.Molecular neurobiology · 2025Review
- Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases.Signal transduction and targeted therapy · 2025Review
- Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms.Heliyon · 2025Review
- The Role of Iron Metabolism in Sepsis-associated Encephalopathy: a Potential Target.Molecular neurobiology · 2024Review
- The Endolysosomal Transporter DMT1 is Required for Morphine Regulation of Neuronal Ferritin Heavy Chain.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2023Article
- Unscrambling the Role of Redox-Active Biometals in Dopaminergic Neuronal Death and Promising Metal Chelation-Based Therapy for Parkinson's Disease.International journal of molecular sciences · 2023Review
- Ebselen, Iron Uptake Inhibitor, Alleviates Iron Overload-Induced Senescence-Like Neuronal Cells SH-SY5Y via Suppressing the mTORC1 Signaling Pathway.Advances in pharmacological and pharmaceutical sciences · 2023Article
- Empirical evidence for biometal dysregulation in Parkinson's disease from a systematic review and Bradford Hill analysis.NPJ Parkinson's disease · 2022Review
- Desferrioxamine Ameliorates Lipopolysaccharide-Induced Lipocalin-2 Upregulation via Autophagy Activation in Primary Astrocytes.Molecular neurobiology · 2022Article
- Inflaming the Brain with Iron.Antioxidants (Basel, Switzerland) · 2021Review
- Hepcidin Promoted Ferroptosis through Iron Metabolism which Is Associated with DMT1 Signaling Activation in Early Brain Injury following Subarachnoid Hemorrhage.Oxidative medicine and cellular longevity · 2021Article
- Opioid Modulation of Neuronal Iron and Potential Contributions to NeuroHIV.Methods in molecular biology (Clifton, N.J.) · 2021Review
- The Relationship Between Protein S-Nitrosylation and Human Diseases: A Review.Neurochemical research · 2020Review
- Regulation of cardiovascular calcium channel activity by post-translational modifications or interacting proteins.Pflugers Archiv : European journal of physiology · 2020Review
- Transmembrane protein western blotting: Impact of sample preparation on detection of SLC11A2 (DMT1) and SLC40A1 (ferroportin).PloS one · 2020Article
- Microglia activation induces oxidative injury and decreases SIRT3 expression in dopaminergic neuronal cells.Journal of neural transmission (Vienna, Austria : 1996) · 2019Article
- DMT1 Expression and Iron Levels at the Crossroads Between Aging and Neurodegeneration.Frontiers in neuroscience · 2019Review
- Nitric Oxide, Iron and Neurodegeneration.Frontiers in neuroscience · 2019Review
Corrections and comments
- Erratum issued
Authors and funding
20 authors at 4 institutions in 2 countries.
Chao LiuDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.ORCID 0000-0003-2352-2533
Cheng-Wu ZhangKey Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, Nanjing 211816, People's Republic of China.
Shun Qiang LoDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.
Seok Ting AngDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.
Katherine Chee Meng ChewDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.ORCID 0000-0003-2051-4386
Dejie YuDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.
Bing Han ChaiDepartment of Research, National Neuroscience Institute, Singapore 308433.
Bobby TanDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.ORCID 0000-0001-9124-0277
Fai TsangDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.
Yee Kit TaiDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.ORCID 0000-0003-0798-3575
Bryce Wei Quan TanDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.
Mui Cheng LiangDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.ORCID 0000-0003-1208-0733
Hwee Tong TanDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596.
Jia Ying TangDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.
Mitchell Kim Peng LaiDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599.ORCID 0000-0001-7685-1424
John Jia En ChuaDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.ORCID 0000-0002-5615-1014
Maxey Ching Ming ChungDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596.
Sanjay KhannaDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.ORCID 0000-0002-7304-6259
Kah-Leong LimDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.ORCID 0000-0002-5440-2588
Tuck Wah SoongDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, phsstw@nus.edu.sg.ORCID 0000-0002-0876-0325
National University of Singapore · SGAgency for Science, Technology and Research · SGNanjing Tech University · CNNational Neuroscience Institute · SG
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elevated iron deposition has been reported in Parkinson's disease (PD). However, the route of iron uptake leading to high deposition in the substantia nigra is unresolved. Here, we show a mechanism in enhanced Fe
Indexed as
LocomotionAnimalsCation Transport ProteinsDopaminergic NeuronsFemaleHumansInflammationIronLipopolysaccharidesMaleMice, TransgenicNitric OxideParkinson DiseaseSolute Carrier Family 11, Member 2Substantia NigraCation Transport ProteinsIronLipopolysaccharidesNitric OxideSolute Carrier Family 11, Member 2DMT1dopaminergic neuronsiron depositionmotoric defectsnitric oxideS-nitrosylation
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.