Evidence map›Paper›PMID 30104343›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

A Transient Developmental Window of Fast-Spiking Interneuron Dysfunction in a Mouse Model of Dravet Syndrome.

Morgana Favero, Nathaniel P Sotuyo, Emily Lopez, Jennifer A Kearney, Ethan M Goldberg

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
8.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 174 citations in OpenAlex.

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  19. Dravet syndrome: novel insights intoFrontiers in neuroscience · 2025
    Review
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37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Morgana FaveroDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, 19104 Philadelphia, Pennsylvania.
Nathaniel P SotuyoDepartment of Neuroscience, The Perelman School of Medicine at The University of Pennsylvania, 19104 Philadelphia, Pennsylvania.
Emily LopezCollege of Arts and Sciences, The University of Pennsylvania, 19104 Philadelphia, Pennsylvania.
Jennifer A KearneyDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, 60611 Chicago, Illinois, and.ORCID 0000-0003-1726-4769
Ethan M GoldbergDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, 19104 Philadelphia, Pennsylvania, goldberge@email.chop.edu.ORCID 0000-0002-7404-735X
Children's Hospital of Philadelphia · USNorthwestern University · USUniversity of Pennsylvania · USUniversity of the Sciences · US

Funding

Genetic Modifiers of Childhood EpilepsyR01NS084959 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KEARNEY, JENNIFER A · 2014 to 2024
$4.2M
Dynamic two-photon calcium imaging and optogenetic manipulation of epileptic brain circuits in an experimental model of temporal lobe epilepsyK08NS097633 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI GOLDBERG, ETHAN M · 2016 to 2020
$921k
NINDS NIH HHS K08 NS097633NINDS NIH HHS R01 NS084959
6 · The paper itself

Abstract

Dravet syndrome is a severe, childhood-onset epilepsy largely due to heterozygous loss-of-function mutation of the gene

Indexed as

Action PotentialsAnimalsAxon Initial SegmentDisease Models, AnimalEpilepsies, MyoclonicInterneuronsMice, KnockoutNAV1.1 Voltage-Gated Sodium ChannelSeizuresSomatosensory CortexNAV1.1 Voltage-Gated Sodium ChannelScn1a protein, mouseDravet syndromeepilepsyfast-spiking interneuronsinterneuronsNav1.1SCN1A

Identifiers

PMID30104343
PMCPMC6125809
OpenAlexW2887582341

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.