Evidence map›Paper›PMID 30104298›Full record

ArticleDiabetes care2018

Burden of Urological Complications in Men and Women With Long-standing Type 1 Diabetes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Cohort.

Hunter Wessells, Barbara H Braffett, Sarah K Holt, Alan M Jacobson, John W Kusek, Catherine Cowie, Rodney L Dunn, Aruna V Sarma, DCCT/EDIC Study Group

Open access · bronzeAbstract read
In one paragraph

Article in Diabetes care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 39 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Mitochondrial dysfunction in urologic disease.Prostate cancer and prostatic diseases · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Urologic complications in diabetes.Journal of diabetes and its complications · 2022
    Review
  11. Sexual dysfunction in women with type 1 diabetes in Norway: A qualitative study of women's experiences.Diabetic medicine : a journal of the British Diabetic Association · 2022
    Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. IR-61 Improves Voiding FunctionFrontiers in pharmacology · 2021
    Article
  17. Autonomic neuropathy and urologic complications in diabetes.Autonomic neuroscience : basic & clinical · 2020
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Hunter WessellsDepartment of Urology and Diabetes Research Center, University of Washington, Seattle, WA wessells@u.washington.edu.ORCID 0000-0003-3584-2323
Barbara H BraffettBiostatistics Center, The George Washington University, Washington, DC.ORCID 0000-0002-2184-9754
Sarah K HoltDepartment of Urology and Diabetes Research Center, University of Washington, Seattle, WA.
Alan M JacobsonNYU Winthrop Research Institute, NYU Winthrop Hospital, Mineola, NY.
John W KusekDivision of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Catherine CowieDivision of Diabetes, Endocrinology, and Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Rodney L DunnDepartments of Urology and Epidemiology, University of Michigan, Ann Arbor, MI.
Aruna V SarmaDepartments of Urology and Epidemiology, University of Michigan, Ann Arbor, MI.
DCCT/EDIC Study Group
National Institutes of Health · USUniversity of Michigan · USUniversity of Washington · USGeorge Washington University · USWinthrop-University Hospital · US

Funding

Limited Competition for the Continuation of Epidemiology of Diabetes Interventions and Complications (EDIC) Study Clinical Research Center (Collaborative U01)U01DK094157 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Ionut Bebu, Barbara Halina Braffett · 2011 to 2026
$97.6M
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4M
Epidemiology of Diabetes Interventions and Complications Data Coordinating CenterU01DK094176 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI BEBU, IONUT, BRAFFETT, BARBARA HALINA · 2012 to 2022
$30.8M
Uro-EDICII: Risk and Progression of Urologic Complications in Type 1- DiabetesR01DK083927 · NIDDK · UNIVERSITY OF WASHINGTON · PI SARMA, ARUNA V, WESSELLS, HUNTER · 2009 to 2013
$2.7M
NIDDK NIH HHS P30 DK017047NIDDK NIH HHS R01 DK083927NIDDK NIH HHS U01 DK094157NIDDK NIH HHS U01 DK094176
6 · The paper itself

Abstract

objectiveType 1 diabetes has been associated with high rates of urinary and sexual problems, but the cumulative burden and overlap of these complications are unknown. We sought to determine prevalence of urological complications in persons with type 1 diabetes, associations with clinical and diabetes-related factors, and rates of emergence, persistence, and remission. RESEARCH DESIGN AND

methodsThis ancillary longitudinal study among participants in the Diabetes Control and Complications Trial (DCCT) and observational follow-up study Epidemiology of Diabetes Interventions and Complications (EDIC) (652 women and 713 men) was conducted in 2003 and 2010/2011. Urinary incontinence (UI), lower urinary tract symptoms, urinary tract infection, female sexual dysfunction, erectile dysfunction, low male sexual desire, and orgasmic dysfunction were measured with validated instruments. Logistic regression determined association of complications with demographics and clinical characteristics.

resultsOf sexually active women completing the 2010/2011 survey, 35% reported no complications, 39% had one, 19% two, 5% three, and 2% four. In men, 31% had no complications, 36% had one, 22% two, 9% three, and 3% four. Sexual dysfunction was most prevalent (42% women and 45% men) followed by UI in women (31%) and low sexual desire in men (40%). Urological complications were associated with age, BMI, and HbA

conclusionsUrological complications are prevalent and frequently co-occur in persons with type 1 diabetes. Remission rates in a minority subset indicate a rationale for future studies to mitigate the onset or impact of urological complications of diabetes.

Indexed as

AdultCost of IllnessDiabetes ComplicationsDiabetes Mellitus, Type 1FemaleHealth SurveysHumansLongitudinal StudiesLower Urinary Tract SymptomsMaleMiddle AgedPrevalenceRandomized Controlled Trials as TopicSexual Dysfunction, PhysiologicalUrologic Diseases

Identifiers

PMID30104298
PMCPMC6150428
OpenAlexW2886656626

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.