Evidence map›Paper›PMID 30104273›Full record

ArticleAntimicrobial agents and chemotherapy2018

Candida albicans Zn Cluster Transcription Factors Tac1 and Znc1 Are Activated by Farnesol To Upregulate a Transcriptional Program Including the Multidrug Efflux Pump

Zhongle Liu, John M Rossi, Lawrence C Myers

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Antimicrobial agents and chemotherapy · 2025
    Article
  4. Review
  5. Article
  6. Absence of farnesol salvage inApplied and environmental microbiology · 2024
    Article
  7. Physiological adventures inMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Participation of the ABC TransporterJournal of fungi (Basel, Switzerland) · 2021
    Article
  14. Intraspecies heterogeneity in microbial interactions.Current opinion in microbiology · 2021
    Review
  15. PDR TransporterFrontiers in microbiology · 2021
    Article
  16. Inhibiting roles of farnesol and HOG in morphological switching ofAmerican journal of translational research · 2020
    Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Zhongle LiuDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
John M RossiDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Lawrence C MyersDepartment of Medical Education, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA larry.myers@dartmouth.edu.
Dartmouth College · US

Funding

Mediator regulation of transporters in fluconazole resistant C. albicans mutantsR21AI113390 · NIAID · DARTMOUTH COLLEGE · PI MYERS, LAWRENCE CHRISTOPHER · 2014 to 2015
$446k
Transcription Factor Targets of Cdk8 Dependent Signaling in C. albicansR21AI115253 · NIAID · DARTMOUTH COLLEGE · PI MYERS, LAWRENCE CHRISTOPHER · 2015 to 2016
$446k
NIAID NIH HHS R21 AI113390NIAID NIH HHS R21 AI115253
6 · The paper itself

Abstract

Farnesol, a quorum-sensing molecule, inhibits

Indexed as

Antifungal AgentsCandida albicansDrug Resistance, FungalFarnesolFungal ProteinsGene Expression Regulation, FungalMembrane Transport ProteinsQuorum SensingTranscriptional ActivationTranscription FactorsTranscription, GeneticUp-RegulationZincAntifungal AgentsFarnesolFungal ProteinsMembrane Transport ProteinsTranscription FactorsZincCandida albicansfarnesolzinc cluster transcription factor

Identifiers

PMID30104273
PMCPMC6201089
OpenAlexW2951484294

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.