Evidence map›Paper›PMID 30104216›Full record

ArticleInfection and immunity2018

Glucan-Chitin Particles Enhance Th17 Response and Improve Protective Efficacy of a Multivalent Antigen (rCpa1) against Pulmonary Coccidioides posadasii Infection.

Chiung-Yu Hung, Hao Zhang, Natalia Castro-Lopez, Gary R Ostroff, Payam Khoshlenar, Ambily Abraham, Garry T Cole, Austin Negron, Thomas Forsthuber, Tao Peng and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 51 citations in OpenAlex.

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  16. The Host Response to Coccidioidomycosis.Journal of fungi (Basel, Switzerland) · 2024
    Review
  17. Journal of fungi (Basel, Switzerland) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Chiung-Yu HungDepartment of Biology and South Texas Center for Emerging Infectious Diseases, University of Texas, San Antonio, Texas, USA Chiungyu.Hung@UTSA.edu.
Hao ZhangDepartment of Biology and South Texas Center for Emerging Infectious Diseases, University of Texas, San Antonio, Texas, USA.
Natalia Castro-LopezDepartment of Biology and South Texas Center for Emerging Infectious Diseases, University of Texas, San Antonio, Texas, USA.
Gary R OstroffProgram in Molecular Medicine and Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Payam KhoshlenarProgram in Molecular Medicine and Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Ambily AbrahamProgram in Molecular Medicine and Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Garry T ColeDepartment of Biology and South Texas Center for Emerging Infectious Diseases, University of Texas, San Antonio, Texas, USA.
Austin NegronDepartment of Biology and South Texas Center for Emerging Infectious Diseases, University of Texas, San Antonio, Texas, USA.
Thomas ForsthuberDepartment of Biology and South Texas Center for Emerging Infectious Diseases, University of Texas, San Antonio, Texas, USA.
Tao PengValley Fever Center for Excellence, College of Medicine, University of Arizona, Tucson, Arizona, USA.
John N GalgianiValley Fever Center for Excellence, College of Medicine, University of Arizona, Tucson, Arizona, USA.
Neil M AmpelValley Fever Center for Excellence, College of Medicine, University of Arizona, Tucson, Arizona, USA.
Jieh-Juen YuDepartment of Biology and South Texas Center for Emerging Infectious Diseases, University of Texas, San Antonio, Texas, USA.
Texas Center for Infectious Disease · USUniversity of Arizona · USUniversity of Massachusetts Chan Medical School · US

Funding

UTSA RISE Research Training ProgramR25GM060655 · NIGMS · UNIVERSITY OF TEXAS SAN ANTONIO · PI BAREA-RODRIGUEZ, EDWIN J · 2000 to 2022
$21.6M
Development of a multivalent vaccine against Coccidioides infectionR01AI135005 · NIAID · UNIVERSITY OF TEXAS SAN ANTONIO · PI HUNG, CHIUNG-YU · 2018 to 2022
$1.9M
Enhancement of protective efficacy of Coccidioides vaccines by adjuvantsR21AI114762 · NIAID · UNIVERSITY OF TEXAS SAN ANTONIO · PI HUNG, CHIUNG-YU · 2015 to 2016
$439k
NIAID NIH HHS R01 AI135005NIAID NIH HHS R21 AI114762NIGMS NIH HHS R25 GM060655
6 · The paper itself

Abstract

Developing an effective and safe recombinant vaccine requires microbe-specific antigens combined with an adjuvant/delivery system to strengthen protective immunity. In this study, we designed and expressed a multivalent recombinant

Indexed as

Adjuvants, ImmunologicAnimalsAntigens, ProtozoanChitinCoccidioidesCoccidioidomycosisDisease Models, AnimalDrug Delivery SystemsGlucansHLA-DR4 AntigenHumansMice, Inbred C57BLMice, TransgenicNanoparticlesOligodeoxyribonucleotidesProtein BindingAdjuvants, ImmunologicAntigens, ProtozoanChitinCPG-oligonucleotideGlucansHLA-DR4 AntigenOligodeoxyribonucleotidesProtozoan VaccinesRecombinant Fusion ProteinsVaccines, SyntheticCoccidioidescoccidioidomycosisfungal vaccineHLA-DR transgenic miceTh17Th17 response and adaptive immunityvaccine immunity

Identifiers

PMID30104216
PMCPMC6204714
OpenAlexW2887612837

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.