SynthesisEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology2018
A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response.
Open access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 37% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- The IMAGEN study: a decade of imaging genetics in adolescents.Molecular psychiatry · 2020Pooled it
- Investigating genetic overlap of multidimensional pain and suicidal behaviors in >2 million individuals.Research square · 2026Article
- Shared genetic variants across substance use disorders implicate common neurobiological pathways, a genome-wide mixed methods study.General psychiatry · 2026Article
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- Modulatory Neurotransmitter Genotypes Shape Dynamic Functional Connectome Reconfigurations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Sleep bruxism in children, from evidence to the clinic. A systematic review.Frontiers in oral health · 2023Review
- Individual differences in cocaine-induced conditioned place preference in male rats: Behavioral and transcriptomic evidence.Journal of psychopharmacology (Oxford, England) · 2022Article
- Genetic influences impacting nicotine use and abuse during adolescence: Insights from human and rodent studies.Brain research bulletin · 2022Review
- Prenatal Effects of Nicotine on Obesity Risks: A Narrative Review.International journal of environmental research and public health · 2022Review
- Effects of OPRM1 and DRD2 on brain structure in drug-naïve adolescents: Genetic and neural vulnerabilities to substance use.Psychopharmacology · 2022Article
- Methylation quantitative trait locus rs5326 is associated with susceptibility and effective dosage of methadone maintenance treatment for heroin use disorder.Psychopharmacology · 2021Article
- Identifying common genome-wide risk genes for major psychiatric traits.Human genetics · 2020Article
- The Impact of Genes on Adolescent Substance Use: A Developmental Perspective.Current addiction reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors at 20 institutions in 9 countries.
Christine MacareInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Centre for Population Neuroscience and Precision Medicine (PONS), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Francesca DucciInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Centre for Population Neuroscience and Precision Medicine (PONS), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; St George's, University of London, London, United Kingdom.
Yuning ZhangInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Centre for Population Neuroscience and Precision Medicine (PONS), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Barbara RuggeriInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Centre for Population Neuroscience and Precision Medicine (PONS), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Tianye JiaInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Centre for Population Neuroscience and Precision Medicine (PONS), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China and Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, China.
Marika KaakinenSection of Genomics of Common Disease, Department of Medicine, Imperial College London, London, United Kingdom; Centre for Pharmacology and Therapeutics, Department of Medicine, Imperial College London, London, United Kingdom.
Gursharan KalsiClinical Physics, Barts Health NHS Trust, The Royal London Hospital, London, UK; One Small Step Gait Laboratory, Guy׳s and St. Thomas' NHS Foundation Trust, Guy׳s Hospital, London, UK.
Pimphen CharoenUCL Institute of Health Informatics, University College, London, UK.
Filippo CasoniDivision of Neuroscience, San Raffaele Scientific Institute, Milan 20132, Italy; Università Vita-Salute San Raffaele, Milan 20132, Italy.
Jan PetersIntelligent Autonomous Systems Group, Department of Computer Science, Technische Universität Darmstadt, Darmstadt, Germany; Max Planck Institute for Intelligent Systems, Tübingen, Germany.
Uli BrombergUniversity Medical Centre Hamburg-Eppendorf, House W34, 3.OG, Martinistr. 52, 20246, Hamburg, Germany.
Matthew HillInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Jessica BuxtonUCL Great Ormond Street Institute of Child Health, London; School of Life Sciences, Pharmacy and Chemistry, Kingston University, Kingston upon Thames, UK.
Alexandra BlakemoreDivision of Diabetes, Endocrinology and Metabolism, Faculty of Medicine, Imperial College London, London, United Kingdom.
Juha VeijolaDepartment of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, Oulu, Finland; Cambridge Cognition Ltd, Cambridge, UK.
Christian BüchelUniversity Medical Centre Hamburg-Eppendorf, House W34, 3.OG, Martinistr. 52, 20246, Hamburg, Germany.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry, Central Institute of Mental Health, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
Arun L W BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Patricia ConrodInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Department of Psychiatry, Universite de Montreal, CHU Ste Justine Hospital, Montreal, Canada.
Herta FlorDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany; Department of Psychology, School of Social Sciences, University of Mannheim, 68131 Mannheim, Germany.
Vincent FrouinNeuroSpin, Bât 145 Gif-sur-Yvette, Paris, France.
Jürgen GallinatClinic for Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hugh GaravanDepartments of Psychiatry and Psychology, University of Vermont, 05405 Burlington, Vermont, USA.
Penny A GowlandSir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham, United Kingdom.
Andreas HeinzClinic for Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Bernd IttermannPhysikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany.
Mark LathropDepartment of Human Genetics, McGill University, 1205 Dr Penfield Avenue, Montreal, QC, Canada; McGill University, Genome Quebec Innovation Centre, 740 Doctor Penfield Avenue, Montreal, QC, Canada.
Jean-Luc MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Sud - Paris Saclay, University Paris Descartes; DIGITEO labs, Gif sur Yvette; France.
Tomáš PausBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital and Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Sylvane DesrivièresInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Centre for Population Neuroscience and Precision Medicine (PONS), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Marcus MunafòMRC Integrative Epidemiology Unit, UK Centre for Tobacco Control Studies and School of Experimental Psychology, University of Bristol, Bristol, United Kingdom.
Marjo-Riitta JärvelinInstitute of Health Sciences, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, United Kingdom; Unit of Primary Care, Oulu University Hospital, Oulu, Finland; Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland.
Gunter SchumannInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Centre for Population Neuroscience and Precision Medicine (PONS), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom. Electronic address: gunter.schumann@kcl.ac.uk.
IMAGEN Consortium
King's College London · GBOulu University Hospital · FIImperial College London · GBUniversity College London · GBUniversity of Oulu · FICambridge Cognition (United Kingdom) · GBCardiff University · GBCharité - Universitätsmedizin Berlin · DEGuy's and St Thomas' NHS Foundation Trust · GBHeidelberg University · DEMax Planck Institute for Intelligent Systems · DEMcGill University and Génome Québec Innovation Centre · CASan Raffaele University of Rome · ITSt George's, University of London · GBTrinity College Dublin · IEUniversität Hamburg · DEUniversité Paris Cité · FRUniversity Hospital Heidelberg · DEUniversity Medical Center Hamburg-Eppendorf · DEUniversity of Bristol · GB
Funding
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MGenetics of cardiovascular risk factors in large founder population birth controlR01HL087679 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HIRSCHHORN, JOEL N · 2007 to 2009
$4.0MWhole Genome Assoc. Analysis Strategies for Multi. PhenotypesRL1MH083268 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B. · 2007 to 2011
$2.1MAxon, Testosterone and Mental Health during AdolescenceR01MH085772 · NIMH · BAYCREST CENTRE FOR GERIATRIC CARE · PI PAUS, TOMAS · 2010 to 2014
$1.5MMedical Research Council 93558Medical Research Council G9815508Medical Research Council MC_UU_00011/7Medical Research Council MR/K023195/1Medical Research Council MR/N000390/1NHLBI NIH HHS R01 HL087679NIBIB NIH HHS U54 EB020403NIMH NIH HHS R01 MH085772NIMH NIH HHS RL1 MH083268Wellcome Trust 092731
Abstract
The TTC12-ANKK1-DRD2 gene-cluster has been implicated in adult smoking. Here, we investigated the contribution of individual genes in the TTC12-ANKK1-DRD2 cluster in smoking and their association with smoking-associated reward processing in adolescence. A meta-analysis of TTC12-ANKK1-DRD2 variants and self-reported smoking behaviours was performed in four European adolescent cohorts (N = 14,084). The minor G-allele of rs2236709, mapping TTC12, was associated with self-reported smoking (p = 5.0 × 10
Indexed as
RewardAdolescentAdolescent BehaviorAnticipation, PsychologicalBehavior, AddictiveBrainCotinineFemaleGenetic Association StudiesGenetic VariationHumansMagnetic Resonance ImagingMaleProteinsProtein Serine-Threonine KinasesReceptors, Dopamine D2ANKK1 protein, humanCotinineDRD2 protein, humanProteinsProtein Serine-Threonine KinasesReceptors, Dopamine D2TTC12 protein, humanfMRIGeneticsIMAGEN-ALSPAC-NFBCMeta-analysisRisk takingSmoking
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.