Evidence map›Paper›PMID 30103941›Full record

ArticleCellular immunology2018

Anti-LFA-1 induces CD8 T-cell dependent allograft tolerance and augments suppressor phenotype CD8 cells.

Robert J Plenter, Todd J Grazia, Marilyne G Coulombe, Michelle K Nelsen, Christine M Lin, K Scott Beard, Tinalyn M Kupfer, Martin R Zamora, Ronald G Gill, Biagio A Pietra

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Robert J PlenterDept. of Surgery, Colorado Center for Transplantation Care, Research and Education, University of Colorado Denver, Aurora, CO, United States; Dept. of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Aurora, CO, United States. Electronic address: Robert.Plenter@ucdenver.edu.
Todd J GraziaDept. of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Aurora, CO, United States; Dept. of Immunology and Microbiology, University of Colorado Denver, Aurora, CO, United States.
Marilyne G CoulombeDept. of Surgery, Colorado Center for Transplantation Care, Research and Education, University of Colorado Denver, Aurora, CO, United States.
Michelle K NelsenDept. of Surgery, Colorado Center for Transplantation Care, Research and Education, University of Colorado Denver, Aurora, CO, United States; Dept. of Immunology and Microbiology, University of Colorado Denver, Aurora, CO, United States.
Christine M LinDivision of Pulmonary, Critical Care & Sleep Medicine, University Florida, Gainesville, FL, United States.
K Scott BeardDept. of Surgery, Colorado Center for Transplantation Care, Research and Education, University of Colorado Denver, Aurora, CO, United States.
Tinalyn M KupferDept. of Surgery, Colorado Center for Transplantation Care, Research and Education, University of Colorado Denver, Aurora, CO, United States.
Martin R ZamoraDept. of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Aurora, CO, United States.
Ronald G GillDept. of Surgery, Colorado Center for Transplantation Care, Research and Education, University of Colorado Denver, Aurora, CO, United States.
Biagio A PietraDept. of Pediatrics, Division of Cardiology, University of Colorado Denver, Aurora, CO, United States; Div. of Pediatric Cardiology, University of Florida, Gainesville, FL, United States.
University of Colorado Denver · USUniversity of Florida · US

Funding

UCHSC DIABETES ENDOCRINOLOGY RESEARCH CENTERP30DK057516 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI HUTTON, JOHN C · 2000 to 2010
$14.0M
IMMUNOBIOLOGY OF PANCREATIC ISLET XENOGRAFTINGR01DK045773 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI GILL, RONALD G · 1993 to 2006
$1.4M
CD4 T cell Dependent Acute Cardiac Allograft RejectionR01HL067976 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI PIETRA, BIAGIO A · 2001 to 2004
$1.2M
NHLBI NIH HHS R01 HL067976NIDDK NIH HHS P30 DK057516NIDDK NIH HHS R01 DK045773
6 · The paper itself

Abstract

The induction of tolerance to transplanted organs is a major objective in transplantation immunology research. Lymphocyte function-associated antigen-1 (LFA-1) interactions have been identified as a key component of the T-cell activation process that may be interrupted to lead to allograft tolerance. In mice, αLFA-1 mAb is a potent monotherapy that leads to the induction of donor-specific transferable tolerance. By interrogating important adaptive and innate immunity pathways, we demonstrate that the induction of tolerance relies on CD8

Indexed as

AnimalsAntibodies, MonoclonalCD28 AntigensCD8-Positive T-LymphocytesCyclosporineFemaleGraft RejectionGraft SurvivalImmune ToleranceImmunity, InnateLymphocyte ActivationLymphocyte Function-Associated Antigen-1Mice, Inbred BALB CMice, Inbred C3HMice, Inbred C57BLMice, TransgenicAntibodies, MonoclonalCD28 AntigensCyclosporineLymphocyte Function-Associated Antigen-1SirolimusRejectionSuppressor cellsTolerance

Identifiers

PMID30103941
PMCPMC6174680
OpenAlexW2887915934

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.