ReviewProstaglandins, leukotrienes, and essential fatty acids2018
Ischemia-modified albumin: Crosstalk between fatty acid and cobalt binding.
Review in Prostaglandins, leukotrienes, and essential fatty acids, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- The HepG2 Cell Line as a Model for Studying Metabolic Dysfunction-Associated Steatotic Liver Disease.International journal of molecular sciences · 2026Review
- Characteristics of the Fatty Acid Composition in Elderly Patients with Occupational Pathology from Organophosphate Exposure.Diagnostics (Basel, Switzerland) · 2025Article
- The Predictive Role of Thiol/Disulfide Homeostasis as an Oxidative Stress Parameter in Sarcopenic Obesity.Medicina (Kaunas, Lithuania) · 2025Article
- Recurrent aphthous stomatitis, oxidative stress, and ischemia modified albumin: A cross-sectional study.Medicine · 2025Observational
- Analytical Insights into Methods for Measuring Ischemia-Modified Albumin.Molecules (Basel, Switzerland) · 2024Review
- An Update Overview on Mechanistic Data and Biomarker Levels in Cobalt and Chromium-Induced Neurodegenerative Diseases.Biological trace element research · 2024Review
- Association of Ischemia-Modified Albumin (IMA) in Saliva, Serum, and Urine with Diagnosis of Chronic Kidney Disease (CKD) in Children: A Case-Control Study.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Markers of Oxidative Stress in Patients with Acne: A Literature Review.Life (Basel, Switzerland) · 2023Review
- Structural and biochemical characterisation of CoChemical science · 2023Article
- Evaluation of Serum Ischemia Modified Albumin in Patients With COVID-19 Pneumonia: A Case-Control Study.Cureus · 2022Article
- Albumin-mediated extracellular zinc speciation drives cellular zinc uptake.Chemical communications (Cambridge, England) · 2022Article
- Ischemia-Modified Albumin-A Potential New Marker of Oxidative Stress in Dermatological Diseases.Medicina (Kaunas, Lithuania) · 2022Review
- Oxidative Stress Biomarkers in Age-Related Lower Urinary Tract Disorders: A Systematic Review.International neurourology journal · 2022Article
- Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality.eLife · 2021Article
- Increase in Ischemia-Modified Albumin and Pregnancy-Associated Plasma Protein-A in COVID-19 Patients.Journal of clinical medicine · 2021Article
- Review
- Ischemia-Modified Albumin: Origins and Clinical Implications.Disease markers · 2021Review
- Intestinal fatty acid-binding protein as a biomarker for the diagnosis of strangulated intestinal obstruction: A meta-analysis.Open medicine (Warsaw, Poland) · 2021Article
- The effects of iron overload, insulin resistance and oxidative stress on metabolic disorders in patients with β- thalassemia major.Journal of diabetes and metabolic disorders · 2020Article
- Novel Invasive and Noninvasive Cardiac-Specific Biomarkers in Obesity and Cardiovascular Diseases.Metabolic syndrome and related disorders · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Myocardial ischemia is difficult to diagnose effectively with still few well-defined biochemical markers for identification in advance, or in the absence of myocardial necrosis. "Ischemia-modified albumin" (IMA), a form of albumin displaying reduced cobalt-binding affinity, is significantly elevated in ischemic patients, and the albumin cobalt-binding (ACB) assay can measure its level indirectly. Elucidating the molecular mechanism underlying the identity of IMA and the ACB assay hinges on understanding metal-binding properties of albumin. Albumin binds most metal ions and harbours four primary metal binding sites: site A, site B, the N-terminal site (NTS), and the free thiol at Cys34. Previous efforts to clarify the identity of IMA and the causes for its reduced cobalt-binding capacity were focused on the NTS site, but the degree of N-terminal modification could not be correlated to the presence of ischemia. More recent work suggested that Co
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.