ArticleBMC surgery2018
Relevant prognostic factors influencing outcome of patients after surgical resection of distal cholangiocarcinoma.
Article in BMC surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Does adjuvant therapy improve survival in patients undergoing pancreaticoduodenectomy for distal cholangiocarcinoma? A systematic review, meta-analysis and meta-regression.Updates in surgery · 2026Pooled it
- Prognostic Significance of Platelet-to-Lymphocyte Ratio in Cholangiocarcinoma: A Meta-Analysis.BioMed research international · 2018Pooled it
- Development and temporal validation of nomograms and machine learning models for predicting overall and cancer-specific survival in primary distal cholangiocarcinoma: a SEER-based study.Translational cancer research · 2026Article
- Histologic patterns of venous invasion in distal extrahepatic bile duct carcinoma correlate with prognosis.Virchows Archiv : an international journal of pathology · 2026Article
- Improved prognostic predictability of the latest Japanese TNM Classification in patients undergoing resection for distal cholangiocarcinoma.Global health & medicine · 2025Article
- Clinical impact of pancreatic invasion in T1-stage distal bile duct cancer and prognostic factors associated with long-term survival: A multicenter study.Journal of hepato-biliary-pancreatic sciences · 2024Article
- The short- and long-term outcomes of pancreaticoduodenectomy for distal cholangiocarcinoma.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2022Article
- Surgical Treatment of Distal Cholangiocarcinoma.Current oncology (Toronto, Ont.) · 2022Review
- Long-term survival in patients with distal cholangiocarcinoma after pancreaticoduodenectomy combined with portal vein system resection and reconstruction.Langenbeck's archives of surgery · 2021Article
- The Efficacy of S-1 as Adjuvant Chemotherapy for Resected Biliary Tract Carcinoma: A Propensity Score-Matching Analysis.Journal of clinical medicine · 2021Article
- Prognostic impact of lymph node parameters in distal cholangiocarcinoma after pancreaticoduodenectomy.World journal of surgical oncology · 2020Article
- Diagnostic-therapeutic management of bile duct cancer.World journal of clinical cases · 2019Review
- Essential updates to the surgical treatment of biliary tract cancer.Annals of gastroenterological surgery · 2019Article
- Preoperative Alkaline Phosphatase-adjusted CA19-9 as a Superior Prognosticator for Extrahepatic Biliary Tract Cancer With Jaundice.Cancer diagnosis & prognosisArticle
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10 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDistal cholangiocarcinoma (DCC) is a rare but over the last decade increasing malignancy and is associated with poor prognosis. According to the present knowledge curative surgery is the only chance for long term survival. This study was performed to evaluate prognostic factors for the outcome of patients undergoing curative surgery for distal cholangiocarcinoma.
methods75 patients who underwent surgery between January 2000 and December 2014 for DCC in curative intention were analysed retrospectively. Potential prognostic factors for survival were investigated including the extent of surgery using purposeful selection of covariates in multivariable Cox regression modeling.
resultsPreoperative biliary stenting (Hazard ratio (HR): 2.530; 95%-CI: 1.146-6.464, p = 0.020), the extent of surgery in case of positive histological venous invasion (HR: 1.209; 95%-CI: 1.017-1.410, p = 0.032), lymph node staging (HR: 2.183; 95%-CI: 1.250-3.841, p = 0.006), perineural invasion (HR: 2.118; 95%-CI: 1.147-4.054, p = 0.016) and postoperative complications graded in points according to Clavien-Dindo (HR: 1.395; 95%-CI: 1.148-1.699, p = 0.001) were indentified as independent significant risk factors for survival. Patients receiving preoperative biliary stenting showed prolonged duration between onset of symptoms and date of operation (p = 0.048).
conclusionsPreoperative biliary stenting reduces survival possibly due to delayed surgery. The extent of surgery is not an independent risk factor for survival except for patients with concomitant histological venous invasion. Oncological factors and postoperative surgical complications are independent prognostic factors for survival.
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