ArticleBMC geriatrics2018
Early life stress and frailty in old age: the Helsinki birth cohort study.
Article in BMC geriatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Healthcare utilisation patterns among frail individuals aged 50+ years: results from the Lolland-Falster Population Study (LOFUS).BMJ open · 2026Article
- Adverse Childhood Experiences and Life Course Adversity Related to Geriatric Syndromes: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Using non-invasive behavioral and physiological data to measure biological age in wild baboons.GeroScience · 2024Article
- Association of Childhood Adversity With Frailty and the Mediating Role of Unhealthy Lifestyle: A Lifespan Analysis.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Article
- Understanding the Causes of Frailty Using a Life-Course Perspective: A Systematic Review.Healthcare (Basel, Switzerland) · 2023Review
- Association of unmet basic resource needs with frailty and quality of life among older adults with cancer-Results from the CARE registry.Cancer medicine · 2023Article
- Association of childhood adversity with frailty and the mediating role of unhealthy lifestyle: Findings from the UK biobank.medRxiv : the preprint server for health sciences · 2023Article
- Early-Life Factors as Predictors of Age-Associated Deficit Accumulation Across 17 Years From Midlife Into Old Age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Early-Life War Exposure and Later-Life Frailty Among Older Adults in Vietnam: Does War Hasten Aging?The journals of gerontology. Series B, Psychological sciences and social sciences · 2022Article
- Frailty Risk Prediction Model among Older Adults: A Chinese Nation-Wide Cross-Sectional Study.International journal of environmental research and public health · 2022Article
- The utilization of primary healthcare services among frail older adults - findings from the Helsinki Birth Cohort Study.BMC geriatrics · 2022Article
- Effects of age, period, and cohort on the prevalence of frailty in Chinese older adults from 2002 to 2014.Frontiers in public health · 2022Article
- Gut microbiota-mediated metabolic restructuring aggravates emotional deficits after anesthesia/surgery in rats with preoperative stress.Frontiers in immunology · 2022Article
- The utilization of specialized healthcare services among frail older adults in the Helsinki Birth Cohort Study.Annals of medicine · 2021Article
- Smartphone-Based Prediction Model for Postoperative Cardiac Surgery Outcomes Using Preoperative Gait and Posture Measures.Sensors (Basel, Switzerland) · 2021Article
- Neonatal Maternal Separation Modifies Proteostasis Marker Expression in the Adult Hippocampus.Frontiers in molecular neuroscience · 2021Article
- The Prevalence of Frailty Using Three Different Frailty Measurements in Two Finnish Cohorts Born Before and After the Second World War.The journal of nutrition, health & aging · 2021Article
- Drivers of Frailty from Adulthood into Old Age: Results from a 27-Year Longitudinal Population-Based Study in Sweden.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEvidence suggests that early life stress (ELS) may extend its effect into adulthood and predispose an individual to adverse health outcomes. We investigated whether wartime parental separation, an indicator of severe ELS, would be associated with frailty in old age.
methodsOf the 972 participants belonging to the present sub-study of the Helsinki Birth Cohort Study, 117 (12.0%) had been evacuated abroad unaccompanied by their parents in childhood during World War II. Frailty was assessed at a mean age of 71 years according to Fried's criteria.
resultsThirteen frail men (4 separated and 9 non-separated) and 20 frail women (2 separated and 18 non-separated) were identified. Compared to the non-separated men, men who had been separated had an increased relative risk ratio (RRR) of frailty (age-adjusted RRR 3.93, 95% CI 1.02, 15.11) that persisted after adjusting for several confounders. No associations were observed among women (RRR 0.62; 95% CI 0.13, 2.94).
conclusionsThese preliminary results suggest that ELS might extend its effects not just into adulthood but also into old age, and secondly, that men may be more vulnerable to the long-term effects of ELS.
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