Evidence map›Paper›PMID 30103612›Full record

ArticleAmerican journal of Alzheimer's disease and other dementias2019

Apathy in Preclinical Alzheimer's Disease: Psychometric Validation of the Apathy Evaluation Scale.

Emre Umucu, Mary Wyman, Beatrice Lee, Megan Zuelsdorff, Susan Flowers Benton, Naomi Nystrom, Sterling C Johnson, Cynthia M Carlsson, Sanjay Asthana, Carey E Gleason

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of Alzheimer's disease and other dementias, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Study Partner Report of Apathy in Older Adults is Associated with AD Biomarkers: Findings from the Harvard Aging Brain Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024
    Article
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emre Umucu1 Department of Rehabilitation Sciences, University of Texas at El Paso, El Paso, TX, USA.ORCID 0000-0002-3945-6975
Mary Wyman2 Geriatric Research, Education and Clinical Center, W. S. Middleton Memorial Veterans Hospital, Madison, WI, USA.ORCID 0000-0001-5371-9105
Beatrice Lee4 Department of Rehabilitation Psychology and Special Education, University of Wisconsin-Madison, Madison, WI, USA.
Megan Zuelsdorff5 Center for Demography of Health and Aging, University of Wisconsin-Madison, Madison, WI, USA.
Susan Flowers Benton6 Department of Family Medicine and Community Health, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Naomi Nystrom2 Geriatric Research, Education and Clinical Center, W. S. Middleton Memorial Veterans Hospital, Madison, WI, USA.
Sterling C Johnson2 Geriatric Research, Education and Clinical Center, W. S. Middleton Memorial Veterans Hospital, Madison, WI, USA.
Cynthia M Carlsson2 Geriatric Research, Education and Clinical Center, W. S. Middleton Memorial Veterans Hospital, Madison, WI, USA.
Sanjay Asthana2 Geriatric Research, Education and Clinical Center, W. S. Middleton Memorial Veterans Hospital, Madison, WI, USA.
Carey E Gleason2 Geriatric Research, Education and Clinical Center, W. S. Middleton Memorial Veterans Hospital, Madison, WI, USA.

Funding

Wisconsin Alzheimer's Disease Research CenterP50AG033514 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI JOHNSON, JEFFREY A · 2009 to 2018
$16.2M
African Americans Fighting Alzheimer’s in Midlife (AA-FAIM)R01AG054059 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CAREY E GLEASON · 2016 to 2026
$15.3M
POPULATION, LIFE COURSE, AND AGINGT32AG000129 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Michal Engelman · 1986 to 2026
$6.0M
NIA NIH HHS P50 AG033514NIA NIH HHS R01 AG054059NIA NIH HHS T32 AG000129
6 · The paper itself

Abstract

objectivesThe purpose of the present study was to validate the Apathy Evaluation Scale, self-rated version (AES-S), and assess the severity of apathy in a cognitively healthy middle-aged cohort at risk for Alzheimer's disease (AD).

methodThree hundred and sixteen middle-aged adults were selected to represent a subset of the Wisconsin Alzheimer's Disease Research Center Clinical Core: the Investigating Memory in People At-risk, Causes and Treatments cohort.

resultsAn exploratory factor analysis (EFA) with varimax rotation identified 3 subscales: apathy, disinterest, and social withdrawal factors. Confirmatory factor analysis confirmed the EFA findings. Results indicated acceptable convergent and discriminant validity. The AES-S is a reliable instrument to quantify apathy in cognitively healthy middle-aged individuals at risk for AD. DISCUSSION: This study demonstrates the AES-S is a psychometrically sound measurement tool for assessing levels of apathy in a cognitively healthy middle-aged cohort at risk for AD.

Indexed as

Prodromal SymptomsAgedAlzheimer DiseaseApathyFemaleHumansMaleMiddle AgedPsychiatric Status Rating ScalesPsychometricsReproducibility of ResultsAlzheimer’s diseaseapathyApathy Evaluation Scalecognitively healthy middle-aged individualspreclinical Alzheimer’s disease

Identifiers

PMID30103612
PMCPMC6642630

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.