ArticleSensors (Basel, Switzerland)2018
Salivary Detection of Dengue Virus NS1 Protein with a Label-Free Immunosensor for Early Dengue Diagnosis.
Article in Sensors (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Longitudinal analysis of viral and host RNA in blood and saliva during controlled human dengue virus 3 infections.Journal of virology · 2026Article
- Development and optimization of self-collected, field stable, saliva-based immunoassays for scalable epidemiological surveillance of pathogen-specific immunity.medRxiv : the preprint server for health sciences · 2026Article
- Electrolyzed saline coolant mitigates bacterial airborne deposition in dental procedures.Frontiers in oral health · 2026Article
- Dengue Fever Diagnosis: Performance Characteristics of Current Tests and Emerging Detection Technologies.Molecular diagnosis & therapy · 2026Review
- Ultra-sensitive fluorescent detection of DENV-2 Nucleocapsid Protein 1 based on CDs-Eu@ZIF-8 modified FeMikrochimica acta · 2025Article
- Biomedical applications of engineered heparin-based materials.Bioactive materials · 2024Review
- Recent Developments in DNA-Nanotechnology-Powered Biosensors for Zika/Dengue Virus Molecular Diagnostics.Nanomaterials (Basel, Switzerland) · 2023Review
- Decadal Journey of CNT-Based Analytical Biosensing Platforms in the Detection of Human Viruses.Nanomaterials (Basel, Switzerland) · 2022Review
- Engineering carbon nanotubes for sensitive viral detection.Trends in analytical chemistry : TRAC · 2022Review
- Highly sensitive detection of dengue biomarker using streptavidin-conjugated quantum dots.Scientific reports · 2021Article
- Dengue Detection: Advances in Diagnostic Tools from Conventional Technology to Point of Care.Biosensors · 2021Review
- Photonics of human saliva: potential optical methods for the screening of abnormal health conditions and infections.Biophysical reviews · 2021Review
- Biosensing strategies for the electrochemical detection of viruses and viral diseases - A review.Analytica chimica acta · 2021Review
- Label-Free Electrochemical Biosensors for the Determination ofSensors (Basel, Switzerland) · 2020Review
- Voltammetric sensing of recombinant viral dengue virus 2 NS1 based on Au nanoparticle-decorated multiwalled carbon nanotube composites.Mikrochimica acta · 2020Article
- Dengue virus: a review on advances in detection and trends - from conventional methods to novel biosensors.Mikrochimica acta · 2019Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue virus (DENV) is a highly pathogenic, arthropod-borne virus transmitted between people by Aedes mosquitoes. Despite efforts to prevent global spread, the potential for DENV epidemics is increasing world-wide. Annually, 3.6 billion people are at risk of infection. With no licensed vaccine, early diagnosis of dengue infection is critical for clinical management and patient survival. Detection of DENV non-structural protein 1 (NS1) is a clinically accepted biomarker for the early detection of DENV infection. Unfortunately, virtually all of the laboratory and commercial DENV NS1 diagnostic methods require a blood draw for sample analysis, limiting point-of-care diagnostics and decreases patient willingness. Alternatively, NS1 in human saliva has been identified for the potential early diagnosis of DENV infection. The collection of saliva is simple, non-invasive, painless, and inexpensive, even by minimally trained personnel. In this study, we present a label-free chemiresistive immunosensor for the detection of the DENV NS1 protein utilizing a network of single-walled carbon nanotubes functionalized with anti-dengue NS1 monoclonal antibodies. NS1 was successfully detected in adulterated artificial human saliva over the range of clinically relevant concentrations with high sensitivity and selectivity. It has potential application in clinical diagnosis and the ease of collection allows for self-testing, even within the home.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.