ReviewInternational journal of molecular sciences2018
Repair of Damaged Articular Cartilage: Current Approaches and Future Directions.
Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
121 citing papers in PubMed.
- Injectable thermosensitive hydrogel incorporating exosome-loaded chitosan microspheres for immunomodulation and cartilage regeneration.Materials today. Bio · 2026Article
- Review
- Association between surgically treated knee injury and knee arthroplasty: an explorative study based on Finnish nationwide register-based data.Acta orthopaedica · 2026Article
- Natural Biomaterials for Osteochondral Repair: From Source to Strategy.Advanced healthcare materials · 2026Review
- Autologous Chondrocyte Implantation on Polyethersulfone Scaffolds in a Rabbit Model of Grade III Lesions.Molecules (Basel, Switzerland) · 2026Article
- InjectableACS biomaterials science & engineering · 2026Article
- Extracellular matrix remodeling in the pathogenesis and therapeutic strategies of rheumatoid arthritis.Clinical and experimental medicine · 2026Review
- Subchondral H-type blood vessel formation aggravates articular cartilage degeneration through LEP-LEPR axis.Frontiers in medicine · 2026Article
- Immunohistochemical evidence for hyaline-like cartilage formation after autologous matrix-induced chondrogenesis for osteochondral lesions of the talus: Case reports of 2 patients.Histology and histopathology · 2025Article
- Potential of human amniotic membrane application for articular cartilage regeneration: a review.Cell and tissue banking · 2025Review
- Platelet-Rich Plasma (PRP): Molecular Mechanisms, Actions and Clinical Applications in Human Body.International journal of molecular sciences · 2025Review
- An Overview of Approaches and Evaluation Methods for Tissue-Engineered Articular Cartilage Constructs in Animal Models.Annals of biomedical engineering · 2025Review
- 2D Chitosan-Based Films: A Proteomic Mass Spectrometry Study of Chondrocyte Phenotype as a Function of Cell-Biomaterial Interactions.International journal of molecular sciences · 2025Article
- Co-delivery of NGF and BMP-2 via thermosensitive pluronic F127 hydrogel enhances chondrogenesis and cartilage repair.Scientific reports · 2025Article
- Advancements in hydrogel applications for osteoarthritis therapy.Nanomedicine (London, England) · 2025Review
- Bioinformatic prediction of key genes involved in pro-chondrogenic effect of fragmentated cartilage transplantation.Scientific reports · 2025Article
- The Use of Gelatin Methacrylate (GelMA) in Cartilage Tissue Engineering: A Comprehensive Review.Bioengineering (Basel, Switzerland) · 2025Review
- Photobiomodulation in Promoting Cartilage Regeneration.International journal of molecular sciences · 2025Review
- Evaluation of the Safety and Regenerative Potential of Human Mesenchymal Stem Cells and Their Extracellular Vesicles in a Transgenic Pig Model of Cartilage-Bone Injury In Vivo - Preclinical Study.Stem cell reviews and reports · 2025Article
- The mechanism of curcumin protecting against IL-1β-induced oxidative stress and inflammation in chondrocytes via the Bmp2/Smad5/Runx2 pathway.Cytotechnology · 2025Article
61 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Articular hyaline cartilage is extensively hydrated, but it is neither innervated nor vascularized, and its low cell density allows only extremely limited self-renewal. Most clinical and research efforts currently focus on the restoration of cartilage damaged in connection with osteoarthritis or trauma. Here, we discuss current clinical approaches for repairing cartilage, as well as research approaches which are currently developing, and those under translation into clinical practice. We also describe potential future directions in this area, including tissue engineering based on scaffolding and/or stem cells as well as a combination of gene and cell therapy. Particular focus is placed on cell-based approaches and the potential of recently characterized chondro-progenitors; progress with induced pluripotent stem cells is also discussed. In this context, we also consider the ability of different types of stem cell to restore hyaline cartilage and the importance of mimicking the environment in vivo during cell expansion and differentiation into mature chondrocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.