Evidence map›Paper›PMID 30103465›Full record

ArticleMolecules (Basel, Switzerland)2018

Fragment-Based Lead Generation of 5-Phenyl-1

Qunchao Wei, Zhichao Zheng, Shijun Zhang, Xuemin Zheng, Fancui Meng, Jing Yuan, Yongnan Xu, Changjiang Huang

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qunchao WeiSchool of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China. wei_qunchao@126.com.
Zhichao ZhengTianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China. zhengzc@tjipr.com.
Shijun ZhangTianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China. zhangsj@tjipr.com.
Xuemin ZhengTianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China. zhengxm@tjipr.com.
Fancui MengTianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China. mengfc@tjipr.com.ORCID 0000-0002-5064-0618
Jing YuanTianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China. yuanj@tjipr.com.
Yongnan XuSchool of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China. ynxu@syphu.edu.cn.
Changjiang HuangTianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China. ynanxu@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

FXIa is suggested as a major target for anticoagulant drug discovery because of reduced risk of bleeding. In this paper, we defined 5-phenyl-1

Indexed as

Drug DesignAnimalsAnticoagulantsFactor XIaHumansMolecular ConformationMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructurePartial Thromboplastin TimeProtein BindingPyrazolesRabbitsStructure-Activity RelationshipAnticoagulantsFactor XIapyrazole-5-carboxamidePyrazolescoagulation factorscomputer-aided drug designdocking stimulationFXIa inhibitorsthrombosis

Identifiers

PMID30103465
PMCPMC6222544

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.