Evidence map›Paper›PMID 30103446›Full record

ArticleInternational journal of molecular sciences2018

Lipidomic Analysis of the Outer Membrane Vesicles from Paired Polymyxin-Susceptible and -Resistant

Raad Jasim, Mei-Ling Han, Yan Zhu, Xiaohan Hu, Maytham H Hussein, Yu-Wei Lin, Qi Tony Zhou, Charlie Yao Da Dong, Jian Li, Tony Velkov

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
0.9field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Virulence · 2025
    Review
  5. Article
  6. Enhanced Outer Membrane Vesicle Production inInternational journal of molecular sciences · 2025
    Article
  7. Review
  8. Loss of Lipooligosaccharide Synthesis inInternational journal of molecular sciences · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Outer-Membrane Vesicles ofMicroorganisms · 2023
    Article
  13. Article
  14. Newly Detected Transmission of blaCurrent medical science · 2023
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Raad JasimDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia. raad.jasim@monash.edu.ORCID 0000-0001-9531-1802
Mei-Ling HanMonash Biomedicine Discovery Institute, Immunity and Infection Program and Department of Microbiology, Monash University, VIC 3800, Australia. meiling.han@monash.edu.
Yan ZhuMonash Biomedicine Discovery Institute, Immunity and Infection Program and Department of Microbiology, Monash University, VIC 3800, Australia. yan.zhu@monash.edu.
Xiaohan HuDepartment of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria 3010, Australia. xiaohanh2@student.unimelb.edu.au.
Maytham H HusseinDepartment of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria 3010, Australia. maytham.hussein@unimelb.edu.au.ORCID 0000-0001-5922-7312
Yu-Wei LinMonash Biomedicine Discovery Institute, Immunity and Infection Program and Department of Microbiology, Monash University, VIC 3800, Australia. yu-wei.lin@monash.edu.
Qi Tony ZhouDepartment of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA. tonyzhou@purdue.edu.
Charlie Yao Da DongDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia. charlie.dong@monash.edu.
Jian LiMonash Biomedicine Discovery Institute, Immunity and Infection Program and Department of Microbiology, Monash University, VIC 3800, Australia. Jian.Li@monash.edu.
Tony VelkovDepartment of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria 3010, Australia. Tony.Velkov@unimelb.edu.au.
Australian Regenerative Medicine Institute · AUThe University of Melbourne · AUMonash University · AUPurdue University West Lafayette · US

Funding

Combating Deadly Gram-negative Lung Infections: An Inhalation and Systems ApproachR01AI132681 · NIAID · PURDUE UNIVERSITY · PI LI, JIAN, ZHOU, QI · 2017 to 2020
$2.4M
NIAID NIH HHS R01 AI132681
6 · The paper itself

Abstract

Gram-negative bacteria produce outer membrane vesicles (OMVs) as delivery vehicles for nefarious bacterial cargo such as virulence factors, which are antibiotic resistance determinants. This study aimed to investigate the impact of polymyxin B treatment on the OMV lipidome from paired polymyxin-susceptible and -resistant

Indexed as

Drug Resistance, BacterialPolymyxin BCell MembraneHumansKlebsiella pneumoniaeMembrane LipidsMembrane LipidsPolymyxin Bextremely drug resistantGram-negativelipidomicsouter membrane vesiclespolymyxin

Identifiers

PMID30103446
PMCPMC6121281
OpenAlexW2887303480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.