Evidence map›Paper›PMID 30103444›Full record

Trial reportNutrients2018

Impact of a Mediterranean Dietary Pattern and Its Components on Cardiovascular Risk Factors, Glucose Control, and Body Weight in People with Type 2 Diabetes: A Real-Life Study.

Marilena Vitale, Maria Masulli, Ilaria Calabrese, Angela Albarosa Rivellese, Enzo Bonora, Stefano Signorini, Gabriele Perriello, Sebastiano Squatrito, Raffaella Buzzetti, Giovanni Sartore and 9 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 8 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 8 syntheses or guidelines pooled it, 148 citations in OpenAlex.

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  14. A Pilot Clinical Trial of a Nutrition Education Program on Quality of Life in CKD.Clinical journal of the American Society of Nephrology : CJASN · 2025
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 10 institutions in 1 country.

Marilena VitaleDepartment of Clinical Medicine and Surgery, Federico II University of Naples, 80131 Naples, Italy. marilena.vitale@unina.it.ORCID 0000-0001-9951-4674
Maria MasulliDepartment of Clinical Medicine and Surgery, Federico II University of Naples, 80131 Naples, Italy. maria.masulli@unina.it.
Ilaria CalabreseDepartment of Clinical Medicine and Surgery, Federico II University of Naples, 80131 Naples, Italy. ilariacalabrese@live.it.
Angela Albarosa RivelleseDepartment of Clinical Medicine and Surgery, Federico II University of Naples, 80131 Naples, Italy. rivelles@unina.it.
Enzo BonoraDivision of Endocrinology, Diabetes and Metabolism, University and Hospital Trust of Verona, 37134 Verona, Italy. enzo.bonora@univr.it.
Stefano SignoriniUniversity Department Laboratory Medicine, Hospital of Desio, 20832 Monza, Italy. s.signorini@asst-monza.it.
Gabriele PerrielloEndocrinology and Metabolism, University of Perugia, 06126, Perugia, Italy. gabriele.perriello@gmail.com.
Sebastiano SquatritoDiabetes Unit, University Hospital Garibaldi-Nesima of Catania, 95122 Catania, Italy. squatrit@unict.it.
Raffaella BuzzettiDepartment of Experimental Medicine, Sapienza University, 04100 Rome, Italy. raffaella.buzzetti@uniroma1.it.
Giovanni SartoreDepartment of Medicine, University of Padua, 35100 Padova, Italy. g.sartore@unipd.it.
Anna Carla BabiniMedical Division, Rimini Hospital, 47900 Rimini, Italy. acbabini@auslrn.net.
Giovanna GregoriDiabetes Unit, Azienda Sanitaria Toscana Nord-Ovest, Massa Carrara, 54100 Massa Carrara, Italy. g.gregori@usl1.toscana.it.
Carla GiordanoSection of Endocrinology, Diabetology and Metabolic Diseases, University of Palermo, 90127 Palermo, Italy. carlagiordano53@gmail.com.
Gennaro ClementeInstitute for Research on Population and Social Policies-National Research Council, 84084 Fisciano, Italy. gennaro.clemente@cnr.it.
Sara GrioniUnità di Epidemiologia e Prevenzione, Fondazione IRCCS, Istituto Nazionale Tumori, 20133 Milano, Italy. sara.grioni@istitutotumori.mi.it.
Pasquale DolceDepartment of Public Health, Federico II University of Naples, 80131 Naples, Italy. pasquale.dolce@unina.it.ORCID 0000-0002-7588-6067
Gabriele RiccardiDepartment of Clinical Medicine and Surgery, Federico II University of Naples, 80131 Naples, Italy. riccardi@unina.it.
Olga VaccaroDepartment of Clinical Medicine and Surgery, Federico II University of Naples, 80131 Naples, Italy. ovaccaro@unina.it.
TOSCA.IT Study Group
University of Naples Federico II · ITFondazione IRCCS Istituto Nazionale dei Tumori · ITInstitute for Research on Population and Social Policies · ITOspedale Garibaldi · ITOspedale Infermi di Rimini · ITSapienza University of Rome · ITUniversity of Padua · ITUniversity of Palermo · ITUniversity of Perugia · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluates the relation of a Mediterranean dietary pattern and its individual components with the cardiovascular risk factors profile, plasma glucose and body mass index (BMI) in people with type 2 diabetes. We studied 2568 participants at 57 diabetes clinics. Diet was assessed with the EPIC (European Prospective Investigation into Cancer and Nutrition) questionnaire, adherence to the Mediterranean diet was evaluated with the relative Mediterranean diet score (rMED). A high compared to a low score was associated with a better quality of diet and a greater adherence to the nutritional recommendations for diabetes. However, even in the group achieving a high score, only a small proportion of participants met the recommendations for fiber and saturated fat (respectively 17% and 30%). Nonetheless, a high score was associated with lower values of plasma lipids, blood pressure, glycated hemoglobin, and BMI. The relationship of the single food items components of the rMED score with the achievement of treatment targets for plasma lipids, blood pressure, glucose, and BMI were also explored. The study findings support the Mediterranean dietary model as a suitable model for type 2 diabetes and the concept that the beneficial health effects of the Mediterranean diet lie primarily in its synergy among various nutrients and foods rather than on any individual component.

Indexed as

Body Mass IndexDiet, HealthyDiet, MediterraneanFeeding BehaviorAgedBiomarkersBlood GlucoseBlood PressureCardiovascular DiseasesCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleGlycated HemoglobinHumansLipidsMaleBiomarkersBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanLipidscardiovascular riskdiabetesglucose controlMediterranean dietplasma lipidsrelative Mediterranean diet score

Identifiers

PMID30103444
PMCPMC6115857
OpenAlexW2886575223

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.