ArticleDevelopmental psychobiology2018
Paternal line effects of early experiences persist across three generations in rhesus macaques.
Article in Developmental psychobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Pooled it
- Doing Science With Our Grandmother's WISDOM: A Worldview Integrating Sociality, Diversity, and Observant Meaning-Making.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Early life adversities and lifelong health outcomes: A review of the literature on large, social, long-lived nonhuman mammals.Neuroscience and biobehavioral reviews · 2023Review
- The relationship of maternal rank, 5-HTTLPR genotype, and MAOA-LPR genotype to temperament in infant rhesus monkeys (Macaca mulatta).American journal of primatology · 2022Article
- Profiling nonhuman primate germline RNA to understand the legacy of early life stress.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2022Article
- Knowledge of Biobehavioral Organization Can Facilitate Better Science: A Review of the BioBehavioral Assessment Program at the California National Primate Research Center.Animals : an open access journal from MDPI · 2021Review
- Parental genetic contributions to neonatal temperament in a nonhuman primate (Macaca mulatta) model.Developmental psychobiology · 2021Article
- The Asthma Family Tree: Evaluating Associations Between Childhood, Parental, and Grandparental Asthma in Seven Chinese Cities.Frontiers in pediatrics · 2021Article
- Rearing condition may alter neonatal development of captive Bolivian squirrel monkeys (Saimiri boliviensis boliviensis).Developmental psychobiology · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The effects of early stress may not be limited to the exposed generation, but are sometimes passed on to subsequent generations. Such non-genetic transgenerational inheritance is a potentially important developmental and evolutionary force. We compared the transgenerational effects of maternal and paternal line early stress on anxiety- and health-related traits in three non-exposed generations (F1, F2 and F3) of semi-naturalistically raised rhesus macaques. As infants, F0 macaques were exposed to nursery rearing (NR) or semi-naturalistic social conditions (CONTROL). Three hundred forty non-exposed F1-F3 descendants were CONTROL reared and physiological and behavioral measures were collected during standardized assessment at 3-4 months of age. Paternal line NR was significantly associated with greater nervousness in F1-F3 and lower immune cell counts in F1-F2. Maternal-line NR effects were not observed. This study suggests that acquired stress-related traits may be "inherited" across generations in primates, through complex social or germ-line mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.