Evidence map›Paper›PMID 30103242›Full record

ArticleThrombosis and haemostasis2018

Genome-Wide Association Study Links Receptor Tyrosine Kinase Inhibitor Sprouty 2 to Thrombocytopenia after Coronary Artery Bypass Surgery.

Jörn A Karhausen, Wenjing Qi, Alan M Smeltz, Yi-Ju Li, Svati H Shah, William E Kraus, Joseph P Mathew, Mihai V Podgoreanu, Miklos D Kertai, Duke Perioperative Genetics Safety Outcomes (PEGASUS) Investigative Team

Open access · bronzeAbstract read
In one paragraph

Article in Thrombosis and haemostasis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jörn A KarhausenDepartment of Anesthesiology, Duke Perioperative Genomics Program, Duke University Medical Center, Duke University, Durham, North Carolina, United States.
Wenjing QiDepartment of Biostatistics and Bioinformatics, Duke University Medical Center, Duke University, Durham, North Carolina, United States.
Alan M SmeltzDepartment of Anesthesiology, Duke Perioperative Genomics Program, Duke University Medical Center, Duke University, Durham, North Carolina, United States.
Yi-Ju LiDepartment of Biostatistics and Bioinformatics, Duke University Medical Center, Duke University, Durham, North Carolina, United States.
Svati H ShahMolecular Physiology Institute, Duke University Medical Center, Duke University, Durham, North Carolina, United States.
William E KrausMolecular Physiology Institute, Duke University Medical Center, Duke University, Durham, North Carolina, United States.
Joseph P MathewDepartment of Anesthesiology, Duke Perioperative Genomics Program, Duke University Medical Center, Duke University, Durham, North Carolina, United States.
Mihai V PodgoreanuDepartment of Anesthesiology, Duke Perioperative Genomics Program, Duke University Medical Center, Duke University, Durham, North Carolina, United States.
Miklos D KertaiDepartment of Anesthesiology, Duke Perioperative Genomics Program, Duke University Medical Center, Duke University, Durham, North Carolina, United States.
Duke Perioperative Genetics Safety Outcomes (PEGASUS) Investigative Team
Duke Medical Center · USDuke University Hospital · US

Funding

Metabolomic Quantitative Trait Locus (mQTL) Genetic Mapping in Human CVDR01HL095987 · NHLBI · DUKE UNIVERSITY · PI SHAH, SVATI H. · 2009 to 2013
$3.4M
Genetics Myocardial Adverse Outcomes/Graft Failure-CABGR01HL075273 · NHLBI · DUKE UNIVERSITY · PI PODGOREANU, MIHAI V. · 2004 to 2008
$3.2M
Genetic Mediators of Metabolic Cardiovascular Disease RiskRC2HL101621 · NHLBI · DUKE UNIVERSITY · PI KRAUS, WILLIAM E · 2009 to 2010
$3.2M
Cross-species analysis of myocardial susceptibility to perioperative stressR01HL092071 · NHLBI · DUKE UNIVERSITY · PI PODGOREANU, MIHAI V. · 2007 to 2010
$1.9M
Lidocaine for Neuroprotection During Cardiac SurgeryR01HL096978 · NHLBI · DUKE UNIVERSITY · PI MATHEW, JOSEPH P · 2009 to 2013
$1.8M
Cortical Beta-amyloid Levels and Neurocognitive Performance After Cardiac SurgeryR21HL108280 · NHLBI · DUKE UNIVERSITY · PI MATHEW, JOSEPH P · 2011 to 2012
$432k
Functional Connectivity Changes In Attention Networks after Cardiac SurgeryR21HL109971 · NHLBI · DUKE UNIVERSITY · PI BROWNDYKE, JEFFREY N, MATHEW, JOSEPH P · 2012 to 2013
$422k
Platelet/Mast Cell Interactions as Determinants of End-Organ Injury in Cardiac SurgeryR56HL126891 · NHLBI · DUKE UNIVERSITY · PI KARHAUSEN, JORN · 2015 to 2015
$414k
NHLBI NIH HHS R01 HL075273NHLBI NIH HHS R01 HL092071NHLBI NIH HHS R01 HL095987NHLBI NIH HHS R01 HL096978NHLBI NIH HHS R21 HL108280NHLBI NIH HHS R21 HL109971NHLBI NIH HHS R56 HL126891NHLBI NIH HHS RC2 HL101621
6 · The paper itself

Abstract

introductionThrombocytopenia after cardiac surgery independently predicts stroke, acute kidney injury and death. To understand the underlying risks and mechanisms, we analysed genetic variations associated with thrombocytopenia in patients undergoing coronary artery bypass grafting (CABG) surgery. MATERIALS AND

methodsStudy subjects underwent isolated on-pump CABG surgery at Duke University Medical Center. Post-operative thrombocytopenia was defined as platelet count < 100 × 10

resultsA total of 63 single-nucleotide polymorphisms met a priori discovery thresholds for replication, but only 1 (rs9574547) in the intergenic region upstream of sprouty 2 (

conclusionWe identified the association of a genetic polymorphism in the intergenic region of

Indexed as

Coronary Artery BypassGenotypeAgedBlood PlateletsCells, CulturedFemaleGene FrequencyGenome-Wide Association StudyHumansIncidenceIntracellular Signaling Peptides and ProteinsMaleMembrane ProteinsMiddle AgedPolymorphism, Single NucleotidePostoperative ComplicationsIntracellular Signaling Peptides and ProteinsMembrane ProteinsSPRY2 protein, human

Identifiers

PMID30103242
PMCPMC6428429
OpenAlexW2887846281

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.