ArticleProceedings of the National Academy of Sciences of the United States of America1986
A molecular mechanism for sensory adaptation based on ligand-induced receptor modification.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 82 citations in OpenAlex.
- Article
- Evolutionary Stability of Small Molecular Regulatory Networks That Exhibit Near-Perfect Adaptation.Biology · 2023Article
- Article
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- Overshoot in biological systems modelled by Markov chains: a non-equilibrium dynamic phenomenon.IET systems biology · 2014Article
- Data-driven quantification of the robustness and sensitivity of cell signaling networks.Physical biology · 2013Article
- The Neurospora photoreceptor VIVID exerts negative and positive control on light sensing to achieve adaptation.Molecular systems biology · 2013Article
- Cooperative adaptive responses in gene regulatory networks with many degrees of freedom.PLoS computational biology · 2013Article
- Robustness of self-organizing chemoattractant field arising from precise pulse induction of its breakdown enzyme: a single-cell level analysis of PDE expression in Dictyostelium.Biophysical journal · 2013Article
- Common dynamical features of sensory adaptation in photoreceptors and olfactory sensory neurons.Scientific reports · 2013Article
- Modelling the regulation of thermal adaptation in Candida albicans, a major fungal pathogen of humans.PloS one · 2012Article
- Article
- Design and diversity in bacterial chemotaxis: a comparative study in Escherichia coli and Bacillus subtilis.PLoS biology · 2004Article
- Kinetic model of the inositol trisphosphate receptor that shows both steady-state and quantal patterns of Ca2+ release from intracellular stores.The Biochemical journal · 2003Article
- Models of eukaryotic gradient sensing: application to chemotaxis of amoebae and neutrophils.Biophysical journal · 2002Article
- A molecular network that produces spontaneous oscillations in excitable cells of Dictyostelium.Molecular biology of the cell · 1998Article
- The calcium sensitivity of individual secretory vesicles is invariant with the rate of calcium delivery.The Journal of general physiology · 1998Article
- Detection and functional characterization of ryanodine receptors from sea urchin eggs.The Journal of physiology · 1998Article
- A model of excitation and adaptation in bacterial chemotaxis.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- A model of excitation and adaptation in bacterial chemotaxis.Biophysical journal · 1995Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
Abstract
Physiological responses mediated by cell-surface receptors frequently adapt or "desensitize" (i.e., terminate despite persistent occupancy of receptors by ligand). Binding of ligands to the external domains of a wide variety of surface receptors induces covalent modification of their cytoplasmic domains. A mechanism is presented in which the variety of receptor states generated by ligand binding and covalent modification act together to regulate physiological responsiveness. The development of the model is guided by observations of adaptation for chemotaxis in Escherichia coli and adenylate cyclase activation in Dictyostelium. The general features of the marked response and eventual exact adaptation predicted by the model match those observed in the experimental systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.