ArticleNeuroImage2018
Increasing beta-amyloid deposition in cognitively healthy aging predicts nonlinear change in BOLD modulation to difficulty.
Article in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Translation of task-evoked negative BOLD response into aging and Alzheimer's disease: a systematic review of the current literature.Journal of translational medicine · 2025Pooled it
- Association of functional brain alterations with β-amyloid, tau, and cognitive decline in Alzheimer's disease.Alzheimer's research & therapy · 2026Article
- Amyloid-beta relates to default and attention network connectivity during working memory retrieval.Brain communications · 2026Article
- Age differences in BOLD modulation to task difficulty as a function of amyloid burden.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Development of a prediction model for cognitive impairment of sarcopenia using multimodal neuroimaging in non-demented older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Neuroimaging Modalities in Alzheimer's Disease: Diagnosis and Clinical Features.International journal of molecular sciences · 2022Review
- Reduced brain activity during a working memory task in middle-aged apolipoprotein E ε4 carriers with overweight/obesity.Frontiers in human neuroscience · 2022Article
- Altered functional hubs and connectivity in type 2 diabetes mellitus with and without mild cognitive impairment.Frontiers in neurology · 2022Article
- PET imaging of neural activity, β-amyloid, and tau in normal brain aging.European journal of nuclear medicine and molecular imaging · 2021Review
- Amyloid-Beta Influences MemoryFrontiers in aging neuroscience · 2021Article
- Brain Amyloid Burden and Resting-State Functional Connectivity in Late Middle-Aged Hispanics.Frontiers in neurology · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Recent evidence indicates that the relationship between increased beta-amyloid (Aβ) deposition and functional task-activation can be characterized by a non-linear trajectory of change in functional activation (Foster et al., 2017), explaining mixed results in prior literature showing both increases and decreases in activation as a function of beta-amyloid burden in cognitively normal adults. Here we sought to replicate this nonlinear effect in the same sample using a different functional paradigm to test the generalizability of this phenomenon. Participants (N = 68 healthy adults aged 49-94) underwent fMRI (0-, 2-, 3-, 4-back working memory task; WM) and
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.