ArticleBJOG : an international journal of obstetrics and gynaecology2019
Fetal microchimerism by mode of delivery: a prospective cohort study.
Article in BJOG : an international journal of obstetrics and gynaecology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Presence of fetal microchimerisms in the heart and effect on cardiac repair.Frontiers in cell and developmental biology · 2024Article
- A history of cesarean section and future maternal long-term risk for neoplasms: a population-based cohort study.Archives of gynecology and obstetrics · 2023Article
- Umbilical Cord Maternal Microchimerism in Normal and Preeclampsia Pregnancies.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Increased fetal microchimerism in immune and stem cell subsets in preeclampsia.American journal of reproductive immunology (New York, N.Y. : 1989) · 2023Article
- Feto-maternal microchimerism: Memories from pregnancy.iScience · 2022Review
- At Preeclampsia Diagnosis, Total Cell-Free DNA Concentration is Elevated and Correlates With Disease Severity.Journal of the American Heart Association · 2021Article
- Predictors of maternal-origin microchimerism in young women in the Philippines.American journal of physical anthropology · 2021Article
- Forever Connected: The Lifelong Biological Consequences of Fetomaternal and Maternofetal Microchimerism.Clinical chemistry · 2021Review
- Nonendocrine mechanisms of sex bias in rheumatic diseases.Nature reviews. Rheumatology · 2019Review
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo compare fetal microchimerism (FMc) in pregnancies with uncomplicated vaginal delivery (VD) versus caesarean delivery (CD).
designProspective cohort study.
settingUniversity of Washington and Fred Hutchinson Cancer Research Center, USA. POPULATION: Women delivering singleton pregnancies without pertinent antenatal complications with uncomplicated deliveries (n = 36).
methodsWe collected maternal predelivery, postdelivery and umbilical cord blood for each mother-baby pair. Following maternal and fetal genotyping, FMc was measured with quantitative polymerase chain reaction assays targeting fetus-specific polymorphisms. Quantification of FMc is expressed as genome equivalents (gEq) of fetal DNA/100 000 total gEq tested. FMc detection was evaluated by logistic regression while controlling for total number of cell equivalents tested and clinically relevant covariates. FMc concentrations were compared using negative binomial regression while controlling for the same covariates and predelivery FMc positivity.
main outcome measureDetection and concentration of FMc by mode of delivery.
resultsTwenty-four mother-baby pairs had a VD and 12 had a CD. Postdelivery FMc detection was higher following CD than after VD (58.3% versus 16.7%, P = 0.02). After controlling for covariates, the likelihood of postdelivery FMc detection was almost nine-fold higher after CD than VD (odds ratio 8.8, 95% CI 1.6-47.6; P = 0.01). With respect to postdelivery FMc concentration, the detection rate ratio for CD versus VD in the adjusted negative binomial regression model was 14.7 (95% CI 3.2-66.8; P = 0.001).
conclusionPostdelivery peripheral FMc detection and concentration are significantly higher after CD than after VD. As FMc is associated with long-term maternal health, our findings suggest that the mode of delivery may impact this risk. TWEETABLE ABSTRACT: Greater fetal microchimerism found in maternal blood following caesarean delivery compared with vaginal delivery.
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