ArticleMedical physics2018
Measuring blood velocity using 4D-DSA: A feasibility study.
Article in Medical physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 23 citations in OpenAlex.
- Interventional Embolization Under Multifactorial Coupling: Mechanisms of Embolic-Agent Distribution and Feasibility of Closed-Loop Automatic Injection.Annals of biomedical engineering · 2026Review
- Middle cerebral artery dissection: pathophysiology, diagnosis, and therapeutic options.Frontiers in neurology · 2025Review
- Quantitative 2-Dimensionsal Digital Subtraction Venography for Venous Interventions: Validation in Phantom and In Vivo Porcine Models.Journal of vascular and interventional radiology : JVIR · 2024Article
- Interleaved x-ray imaging: A method for simultaneous acquisition of quantitative and diagnostic digital subtraction angiography.Medical physics · 2024Article
- Experimental study using phantom models of cerebral aneurysms and 4D-DSA to measure blood flow on 3D-color-coded images.Technology and health care : official journal of the European Society for Engineering and Medicine · 2024Article
- Motion-compensation approach for quantitative digital subtraction angiography and its effect onJournal of medical imaging (Bellingham, Wash.) · 2024Article
- In silico simulation of hepatic arteries: An open-source algorithm for efficient synthetic data generation.Medical physics · 2023Article
- Flat-panel conebeam CT in the clinic: history and current state.Journal of medical imaging (Bellingham, Wash.) · 2021Article
- Virtual 2D angiography from four-dimensional digital subtraction angiography (4D-DSA): A feasibility study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2021Article
- A technique for intra-procedural blood velocity quantitation using time-resolved 2D digital subtraction angiography.CVIR endovascular · 2021Article
- 4D-DSA: Development and Current Neurovascular Applications.AJNR. American journal of neuroradiology · 2021Review
- Optimization of quantitative time-resolved 3D (4D) digital subtraction angiography in a porcine liver model.European radiology experimental · 2020Article
- Optimizing the Quality of 4D-DSA Temporal Information.AJNR. American journal of neuroradiology · 2019Article
- Initial investigation of the use of angiographic parametric imaging for early prognosis of delayed cerebral ischemia in patients with subarachnoid hemorrhage.Proceedings of SPIE--the International Society for Optical EngineeringArticle
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeFour-dimensional (4D) DSA reconstruction provides three-dimensional (3D) time-resolved visualization of contrast bolus passage through arterial vasculature in the interventional setting. The purpose of this study was to evaluate the feasibility of using these data in measuring blood velocity and flow.
methodsThe pulsatile signals in the time concentration curves (TCCs) measured at different points along a vessel are markers of the movement of a contrast bolus and thus of blood flow. When combined with the spatial content, that is, geometry of the vasculature, this information then provides the data required to determine blood velocity. A Fourier-based algorithm was used to identify and follow the pulsatility signal. A Side Band Ratio (SBR) metric was used to reduce uncertainty in identifying the pulsatility in regions where the signal was weak. We tested this method using 4D-DSA reconstructions from vascular phantoms as well as from human studies.
resultsIn five studies using 3D printed patient-specific cerebrovascular phantoms, velocities calculated from the 4D-DSAs were found to be within 10% of velocities measured with a flow meter. Calculated velocity and flow values from three human studies were within the range of those reported in the literature.
conclusions4D-DSA provides temporal and spatial information about blood flow and vascular geometry. This information is obtained using conventional rotational angiographic systems. In this small feasibility study, these data allowed calculations of velocity values that correlated well with measured values. The availability of velocity and blood flow information in the interventional setting would support a more quantitative approach to diagnosis, treatment planning and post-treatment evaluations of a variety of cerebrovascular diseases.
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