ArticlePloS one2018
Phylogenetic and antimicrobial resistance gene analysis of Salmonella Typhimurium strains isolated in Brazil by whole genome sequencing.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Article
- Salmonella isolated from street foods and environment of an urban park: A whole genome sequencing approach.PloS one · 2025Article
- Antimicrobial resistance and genetic background of non-typhoidal Salmonella enterica strains isolated from human infections in São Paulo, Brazil (2000-2019).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- WGS-Based Lineage and Antimicrobial Resistance Pattern ofAntibiotics (Basel, Switzerland) · 2022Article
- Genomic Characterization ofMicroorganisms · 2022Article
- Emergence, Dissemination and Antimicrobial Resistance of the Main Poultry-AssociatedVeterinary sciences · 2022Review
- The Dynamics of the Antimicrobial Resistance Mobilome ofFrontiers in microbiology · 2022Review
- Salmonella Typhimurium ST313 isolated in Brazil revealed to be more invasive and inflammatory in murine colon compared to ST19 strains.Journal of microbiology (Seoul, Korea) · 2021Article
- Insights about the epidemiology of Salmonella Typhimurium isolates from different sources in Brazil using comparative genomics.Gut pathogens · 2021Article
- Recent Advances in the Detection of Antibiotic and Multi-Drug ResistantInternational journal of molecular sciences · 2021Review
- Genomic Analysis of Antimicrobial Resistance and Resistance Plasmids inAntibiotics (Basel, Switzerland) · 2021Article
- Identification of a predominant genotype of Mycobacterium tuberculosis in Brazilian indigenous population.Scientific reports · 2021Article
- Whole-Genome Sequencing Analysis ofPathogens (Basel, Switzerland) · 2021Article
- Serotyping, MLST, and Core Genome MLST Analysis ofFrontiers in microbiology · 2021Article
- Inactivation of Multi-Drug Resistant Non-TyphoidalPathogens (Basel, Switzerland) · 2020Article
- Evolution of Salmonella enterica serotype Typhimurium driven by anthropogenic selection and niche adaptation.PLoS genetics · 2020Article
- Occurrence, quantification, pulse types, and antimicrobial susceptibility of Salmonella sp. isolated from chicken meat in the state of Paraná, Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Phylogenetic analysis revealed that Salmonella Typhimurium ST313 isolated from humans and food in Brazil presented a high genomic similarity.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Frequency of Antimicrobial Resistance Genes inFrontiers in microbiology · 2020Article
- Prevalence and antimicrobial resistance ofIranian journal of veterinary research · 2020Article
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8 authors.
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Abstract
Whole genome sequencing (WGS) has been used as a powerful technology for molecular epidemiology, surveillance, identification of species and serotype, identification of the sources of outbreaks, among other purposes. In Brazil, there is relatively few epidemiological data on Salmonella. In this study, 90 Salmonella Typhimurium strains had their genome sequenced to uncover the diversity of Salmonella Typhimurium isolated from humans and food, between 1983 and 2013, from different geographic regions in Brazil based on single nucleotide polymorphism (SNP) analysis. A total of 39 resistance genes were identified, such as aminoglycoside, tetracycline, sulfonamide, trimethoprim, beta-lactam, fluoroquinolone, phenicol and macrolide, as well as the occurrence of point mutations in some of the genes such as gyrA, gyrB, parC and parE. A total of 65 (72.2%) out of 90 S. Typhimurium strains studied were phenotypically resistant to sulfonamides, 44 (48.9%) strains were streptomycin resistant, 27 (30%) strains were resistant to tetracycline, 21 (23.3%) strains were gentamicin resistant, and seven (7.8%) strains were resistant to ceftriaxone. In the gyrA gene, it was observed the following amino acid substitutions: Asp(87)→Gly, Asp(87)→Asn, Ser(83)→Phe, Ser(83)→Tyr. Phylogenetic results placed the 90 S. Typhimurium strains into two major clades suggesting the existence of a prevalent subtype, likely more adapted, among strains isolated from humans, with some diversity in subtypes in foods. The variety and prevalence of resistant genes found in these Salmonella Typhimurium strains reinforces their potential hazard for humans and the risk in foods in Brazil.
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