ArticlePloS one2018
Cancer- and behavior-related genes are targeted by selection in the Tasmanian devil (Sarcophilus harrisii).
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Genetic Recovery of Two Wild Seatrout Populations Following Long-Term Stocking With Non-Native Conspecifics.Molecular ecology · 2025Article
- Understanding the evolution of immune genes in jawed vertebrates.Journal of evolutionary biology · 2023Review
- Divergent sensory and immune gene evolution in sea turtles with contrasting demographic and life histories.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Whole genome resequencing reveals signatures of rapid selection in a virus-affected commercial fishery.Molecular ecology · 2022Article
- Expression of the Nonclassical MHC Class I, Saha-UD in the Transmissible Cancer Devil Facial Tumour Disease (DFTD).Pathogens (Basel, Switzerland) · 2022Article
- Spatial variation in gene expression of Tasmanian devil facial tumors despite minimal host transcriptomic response to infection.BMC genomics · 2021Article
- Contemporary and historical selection in Tasmanian devils (Proceedings. Biological sciences · 2021Article
- Integrative Analysis of lncRNA-mRNA Coexpression in Human Lung Epithelial Cells Exposed to Dimethyl Selenide-Derived Secondary Organic Aerosols.Chemical research in toxicology · 2021Article
- Bidirectional interactions between host social behaviour and parasites arise through ecological and evolutionary processes.Parasitology · 2021Article
- Emerging infectious disease and the challenges of social distancing in human and non-human animals.Proceedings. Biological sciences · 2020Review
- Transmissible Cancers in an Evolutionary Perspective.iScience · 2020Review
- Changes in spatial organization following an acute epizootic: Tasmanian devils and their transmissible cancer.Global ecology and conservation · 2020Article
- The evolution of resistance and tolerance as cancer defences.Parasitology · 2020Article
- Inference of Selection from Genetic Time Series Using Various Parametric Approximations to the Wright-Fisher Model.G3 (Bethesda, Md.) · 2019Article
- Conserving adaptive potential: lessons from Tasmanian devils and their transmissible cancer.Conservation genetics (Print) · 2019Article
- Sex bias in ability to cope with cancer: Tasmanian devils and facial tumour disease.Proceedings. Biological sciences · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Devil Facial Tumor Disease (DFTD) is an aggressive cancer notorious for its rare etiology and its impact on Tasmanian devil populations. Two regions underlying an evolutionary response to this cancer were recently identified using genomic time-series pre- and post-DTFD arrival. Here, we support that DFTD shaped the genome of the Tasmanian devil in an even more extensive way than previously reported. We detected 97 signatures of selection, including 148 protein coding genes having a human orthologue, linked to DFTD. Most candidate genes are associated with cancer progression, and an important subset of candidate genes has additional influence on social behavior. This confirms the influence of cancer on the ecology and evolution of the Tasmanian devil. Our work also demonstrates the possibility to detect highly polygenic footprints of short-term selection in very small populations.
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