ArticleMedicine and science in sports and exercise2018
Genomewide Association Study of Leisure-Time Exercise Behavior in Japanese Adults.
Article in Medicine and science in sports and exercise, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- A contextual genomic perspective on physical activity and its relationship to health, well being and illness.Nature genetics · 2025Pooled it
- Genetic variants related to physical activity or sedentary behaviour: a systematic review.The international journal of behavioral nutrition and physical activity · 2021Pooled it
- Differential dose-response associations of leisure-time and non-leisure-time physical activity with perceived stress in middle-aged and older adults.Scientific reports · 2026Article
- Genetic Determinants of Leisure-Time Physical Activity in the Taiwanese Population: A Genome-Wide Association Study.Medicine and science in sports and exercise · 2025Article
- Associations between Physical Activity, Sedentary Time, and Locomotive Syndrome Differ by Age and Sex: A Cross-sectional Study.Physical therapy research · 2025Article
- Relationship between Locomotive Syndrome and Cortical Bone Thickness and Trabecular Bone Density in a Community-dwelling Postmenopausal Population.Physical therapy research · 2025Article
- Genetic Background of Acute Heart Rate Response to Exercise.International journal of molecular sciences · 2024Article
- One Cup of Coffee a Day Modulates the Relationship between Metabolic Syndrome and Eating Fast: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2024Article
- Seven-plus hours of daily sedentary time and the subsequent risk of breast cancer: Japan Multi-Institutional Collaborative Cohort Study.Cancer science · 2024Article
- Moderate-to-vigorous Physical Activity and Sedentary Behavior Are Independently Associated With Renal Function: A Cross-sectional Study.Journal of epidemiology · 2023Article
- Genetic Determinants of Leisure-Time Physical Activity in the Hungarian General and Roma Populations.International journal of molecular sciences · 2023Article
- Robust Bioinformatics Approaches Result in the First Polygenic Risk Score for BMI in Greek Adults.Journal of personalized medicine · 2023Article
- Genome-wide assessment reveals a significant association between ACSS3 and physical activity.Genes, brain, and behavior · 2023Article
- Age group differences in psychological distress and leisure-time exercise/socioeconomic status during the COVID-19 pandemic: a cross-sectional analysis during 2020 to 2021 of a cohort study in Japan.Frontiers in public health · 2023Article
- Association between Sedentary Time and Falls among Middle-Aged Women in Japan.Healthcare (Basel, Switzerland) · 2022Article
- Genome-wide association studies of 27 accelerometry-derived physical activity measurements identified novel loci and genetic mechanisms.Genetic epidemiology · 2022Article
- Study Profile of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study.Journal of epidemiology · 2021Article
- Effect of Underlying Cardiometabolic Diseases on the Association Between Sedentary Time and All-Cause Mortality in a Large Japanese Population: A Cohort Analysis Based on the J-MICC Study.Journal of the American Heart Association · 2021Article
- Natural Extracts to Augment Energy Expenditure as a Complementary Approach to Tackle Obesity and Associated Metabolic Alterations.Biomolecules · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
39 authors at 20 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAlthough several genetic factors may play a role in leisure-time exercise behavior, there is currently no evidence of a significant genomewide association, and candidate gene replication studies have produced inconsistent results.
methodsWe conducted a two-stage genomewide association study and candidate single-nucleotide polymorphisms (SNP) association study on leisure-time exercise behavior using 13,980 discovery samples from the Japan Multi-Institutional Collaborative Cohort (J-MICC) study, and 2036 replication samples from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center-2 study. Leisure-time physical activity was measured using a self-administered questionnaire that inquired about the type, frequency and duration of exercise. Participants with ≥4 MET·h·wk of leisure-time physical activity were defined as exhibiting leisure-time exercise behavior. Association testing using mixed linear regression models was performed on the discovery and replication samples, after which the results were combined in a meta-analysis. In addition, we tested six candidate genetic variants derived from previous genomewide association study.
resultsWe found that one novel SNP (rs10252228) located in the intergenic region between NPSR1 and DPY19L1 was significantly associated with leisure-time exercise behavior in discovery samples. This association was also significant in replication samples (combined P value by meta-analysis = 2.2 × 10). Several SNP linked with rs10252228 were significantly associated with gene expression of DPY19L1 and DP19L2P1 in skeletal muscle, heart, whole blood, and the nervous system. Among the candidate SNP, rs12612420 in DNAPTP6 demonstrated nominal significance in discovery samples but not in replication samples.
conclusionsWe identified a novel genetic variant associated with regular leisure-time exercise behavior. Further functional studies are required to validate the role of these variants in exercise behavior.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.