ArticleAIDS (London, England)2018
Carotid artery atherosclerosis is associated with mortality in HIV-positive women and men.
Article in AIDS (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 29 citations in OpenAlex.
- Multi-omics profiles of sex hormone-binding globulin are associated with subclinical atherosclerosis in men with HIV.Genome medicine · 2026Article
- Multi-omics analysis of the gut microbiome and carotid artery atherosclerosis in men with and without HIV.EBioMedicine · 2026Article
- Early Identification of Atherosclerosis in People Living with HIV by Coronary Computed Tomography Angiography.Diagnostics (Basel, Switzerland) · 2026Article
- Coronary artery calcium and all-cause mortality in the Multicenter AIDS Cohort Study.Atherosclerosis · 2025Observational
- No accelerated progression of subclinical atherosclerosis with integrase strand transfer inhibitors compared to non-nucleoside reverse transcriptase inhibitors.The Journal of antimicrobial chemotherapy · 2025Article
- Predictive Model for the Detection of Subclinical Atherosclerosis in HIV Patients on Antiretroviral Treatment.Current HIV research · 2025Observational
- Unseen threat: how subclinical atherosclerosis increases mortality risk in patients with type 1 diabetes.Cardiovascular diabetology · 2024Observational
- Atherosclerosis and Cardiovascular Complications in People Living with HIV: A Focused Review.Infectious disease reports · 2024Review
- Association of carotid atherosclerosis markers with all-cause and cardiovascular disease-specific mortality in persons with type 2 diabetes: a causal mediation analysis with glucose variation.Acta diabetologica · 2024Article
- Subclinical Atherosclerosis Across the Menopausal Transition in Women With and Without HIV.The Journal of infectious diseases · 2024Article
- Article
- Sex Hormones, the Stool Microbiome, and Subclinical Atherosclerosis in Women With and Without HIV.The Journal of clinical endocrinology and metabolism · 2024Article
- Combined effects of smoking and HIV infection on the occurrence of aging-related manifestations.Scientific reports · 2023Article
- Menopausal Hormone Therapy and Subclinical Cardiovascular Disease in Women With and Without Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Sex Differences in Non-AIDS Comorbidities Among People With Human Immunodeficiency Virus.Open forum infectious diseases · 2021Review
- Characteristics of the MACS/WIHS Combined Cohort Study: Opportunities for Research on Aging With HIV in the Longest US Observational Study of HIV.American journal of epidemiology · 2021Observational
- Circulating β-d-Glucan as a Marker of Subclinical Coronary Plaque in Antiretroviral Therapy-Treated People With Human Immunodeficiency Virus.Open forum infectious diseases · 2021Article
- Classical monocyte transcriptomes reveal significant anti-inflammatory statin effect in women with chronic HIV.Cardiovascular research · 2021Article
- Depression and Psychosocial Stress Are Associated With Subclinical Carotid Atherosclerosis Among Women Living With HIV.Journal of the American Heart Association · 2020Observational
- Subclinical Atherosclerosis Markers of Carotid Intima-Media Thickness, Carotid Plaques, Carotid Stenosis, and Mortality in Community-Dwelling Adults.International journal of environmental research and public health · 2020Article
Corrections and comments
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Authors and funding
16 authors at 11 institutions in 1 country.
Funding
Abstract
objectiveAmong people with HIV, there are few long-term studies of noninvasive ultrasound-based measurements of the carotid artery predicting major health events. We hypothesized that such measurements are associated with 10-year mortality in the Women's Interagency HIV Study (WIHS) and Multicenter AIDS Cohort Study (MACS), and that associations differ by HIV serostatus.
designNested cohort study.
methodsParticipants without coronary heart disease underwent B-mode carotid artery ultrasound, with measurement of common carotid artery intima-media thickness (IMT); carotid artery plaque (focal IMT > 1.5 mm) at six locations; and Young's modulus of elasticity, a measure of arterial stiffness. We examined all-cause mortality using Cox models, controlling for demographic, behavioral, cardiometabolic, and HIV-related factors.
resultsAmong 1722 women (median age 40 years, 90% nonwhite, 71% HIV-positive) and 1304 men (median age 50, 39% nonwhite, 62% HIV-positive), 11% died during follow-up. Mortality was higher among HIV-positive women [19.9 deaths/1000 person-years, 95% confidence interval (CI) 14.7-28.8] than HIV-positive men (15.1/1000, 95% CI 8.3-26.8). In adjusted analyses, plaque was associated with mortality (hazard ratio 1.44, 95% CI 1.10-1.88) regardless of HIV serostatus, and varied by sex (among women, hazard ratio 1.06, 95% CI 0.74-1.52; among men; hazard ratio 2.19, 95% CI 1.41-3.43). The association of plaque with mortality was more pronounced among HIV-negative (hazard ratio 3.87, 95% 1.95-7.66) than HIV-positive participants (hazard ratio 1.35, 95% CI 1.00-1.84). Arterial stiffness was also associated with mortality (hazard ratio 1.43 for highest versus lowest quartile, 95% CI 1.02-2.01). Greater common carotid artery-IMT was not associated with mortality.
conclusionCarotid artery plaque was predictive of mortality, with differences observed by sex and HIV serostatus.
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