ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019
Loss of HDAC6 alters gut microbiota and worsens obesity.
Abstract read
In one paragraph
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 50 citations in OpenAlex.
- The histone deacetylase family in health and disease.Signal transduction and targeted therapy · 2026Review
- Phenylacetic Acid, a Gut Microbially Produced Metabolite, Reduces Atherosclerosis Burden and Impacts Host Lipid Homeostasis.Journal of the American Heart Association · 2026Article
- Epigenetic Alterations in Microbiome-Host Interactions in Inflammatory and Autoimmune Diseases.International journal of molecular sciences · 2026Review
- Multiomics strategy-based obesity biomarkers discovery for precision medicine.International journal of obesity (2005) · 2026Review
- Dynamic Rendition of Adipose Genes Under Epigenetic Regulation: Revealing New Mechanisms of Obesity Occurrence.Current issues in molecular biology · 2025Review
- The Impact of Liver Graft Preservation Method on Longitudinal Gut Microbiome Changes Following Liver Transplant: A Proof-of-concept Study.Journal of clinical and translational hepatology · 2025Article
- Role of Protein Lysine Acetylation in the Pathogenesis and Treatment of Obesity and Metabolic Syndrome.Current obesity reports · 2025Review
- Energy metabolism in health and diseases.Signal transduction and targeted therapy · 2025Review
- Genetic deletion or pharmacologic inhibition of histone deacetylase 6 protects the heart against ischaemia/reperfusion injury by limiting tumour necrosis factor alpha-induced mitochondrial injury in experimental diabetes.Cardiovascular research · 2024Article
- Gut microbiota characteristics of colorectal cancer patients in Hubei, China, and differences with cohorts from other Chinese regions.Frontiers in microbiology · 2024Article
- Epigenetic regulation of human FOXP3+ Tregs: from homeostasis maintenance to pathogen defense.Frontiers in immunology · 2024Review
- Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study.Signal transduction and targeted therapy · 2023Review
- Bioinformatics and Next-Generation Data Analysis for Identification of Genes and Molecular Pathways Involved in Subjects with Diabetes and Obesity.Medicina (Kaunas, Lithuania) · 2023Article
- Assessment ofFrontiers in nutrition · 2023Article
- Abnormal intestinal milieu in posttraumatic stress disorder is not impacted by treatment that improves symptoms.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
- Gut microbial metabolites in Parkinson's disease: Association with lifestyle, disease characteristics, and treatment status.Neurobiology of disease · 2022Article
- Article
- The Therapeutic Effect of SCFA-Mediated Regulation of the Intestinal Environment on Obesity.Frontiers in nutrition · 2022Review
- BCAA-BCKA axis regulates WAT browning through acetylation of PRDM16.Nature metabolism · 2022Article
- Epigenetic regulation of energy metabolism in obesity.Journal of molecular cell biology · 2021Review
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 1 country.
Arnon D LieberDepartment of Medicine New York University School of Medicine (NYUSM), New York, New York, USA.
Ulf H BeierDivision of Nephrology, Department of Pediatrics University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Haiyan XiaoDivision of Nephrology, Department of Pediatrics University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Benjamin J WilkinsDivision of Anatomic Pathology, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jing JiaoDivision of Nephrology, Department of Pediatrics University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Xinmin S LiDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Rebecca C SchugarDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Christopher M StrauchDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Zeneng WangDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
J Mark BrownDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Stanley L HazenDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Nicholas A BokulichDepartment of Medicine New York University School of Medicine (NYUSM), New York, New York, USA.
Kelly V RugglesApplied Bioinformatics Laboratories, New York University School of Medicine (NYUSM), New York, New York, USA.
Tatiana AkimovaDivision of Transplant Immunology, Department of Pathology and Laboratory Medicine, Biesecker Center for Pediatric Liver Disease, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Wayne W HancockDivision of Transplant Immunology, Department of Pathology and Laboratory Medicine, Biesecker Center for Pediatric Liver Disease, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Martin J BlaserDepartment of Medicine New York University School of Medicine (NYUSM), New York, New York, USA.
Cleveland Clinic Lerner College of Medicine · USUniversity of Pennsylvania · USNew York University · USVA NY Harbor Healthcare System · US
Funding
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1MTargeting 15-PGDH in Colon Cancer Prognosis, Prediction, Treatment and PreventionP50CA150964 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MARKOWITZ, SANFORD D. · 2011 to 2022
$24.6MDisappearing gastrointestinal microbiota in epidemic obesity.R01DK090989 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BLASER, MARTIN J · 2010 to 2015
$7.4MTransgenic and mutant animalP01AI073489 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI KATSUMATA, MAKOTO · 2008 to 2012
$7.1MMicrobial, immune, metabolic perturbations by antibiotics (MIME study)U01AI122285 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI MARTIN J BLASER, Steven M Holland · 2016 to 2026
$5.2MTargeting Sirtuin-1 to enhance Foxp3+ regulatory T-cell functionK08AI095353 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI BEIER, ULF · 2011 to 2015
$650kANTI-INFLAMMATORY EFFECTS OF TARGETING THE HDAC6/HSP90 PATHWAYR56AI095276 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI HANCOCK, WAYNE WILLIAM · 2011 to 2011
$209kNCI NIH HHS P30 CA016087NCI NIH HHS P50 CA150964NIAID NIH HHS K08 AI095353NIAID NIH HHS P01 AI073489NIAID NIH HHS R56 AI095276NIAID NIH HHS U01 AI122285NIDDK NIH HHS R01 DK090989
Abstract
Alterations in gut microbiota are known to affect intestinal inflammation and obesity. Antibiotic treatment can affect weight gain by elimination of histone deacetylase (HDAC) inhibitor-producing microbes, which are anti-inflammatory by augmenting regulatory T (T
Indexed as
Gastrointestinal MicrobiomeAnimalsBacteroidesDiet, High-FatFatty LiverFecesGerm-Free LifeHistone Deacetylase 6HyperlipidemiasLactobacillusMaleMesenteryMiceMice, Inbred C57BLMice, KnockoutObesityHdac6 protein, mouseHistone Deacetylase 6HDACinflammationmicrobiomeT-regulatory cells
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.