ArticleBioinformatics (Oxford, England)2019
Cell membrane proteins with high N-glycosylation, high expression and multiple interaction partners are preferred by mammalian viruses as receptors.
Article in Bioinformatics (Oxford, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
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- Cellular receptors for mammalian viruses.PLoS pathogens · 2024Article
- TurboID-mediated proximity labeling technologies to identify virus co-receptors.Frontiers in cellular and infection microbiology · 2024Article
- Single-nucleus transcriptome inventory of giant panda reveals cellular basis for fitness optimization under low metabolism.BMC biology · 2023Article
- Prediction of mammalian virus cross-species transmission based on host proteins.Microbiology spectrum · 2023Article
- The Transcriptome Landscape of the In Vitro Human Airway Epithelium Response to SARS-CoV-2.International journal of molecular sciences · 2023Article
- Evolutionary history of type II transmembrane serine proteases involved in viral priming.Human genetics · 2022Article
- Screening of cell-virus, cell-cell, gene-gene crosstalk among animal kingdom at single cell resolution.Clinical and translational medicine · 2022Article
- EVIHVR: A platform for analysis of expression, variation and identification of human virus receptors.Infectious medicine · 2022Article
- VThunter: a database for single-cell screening of virus target cells in the animal kingdom.Nucleic acids research · 2022Article
- Serum ACE2 Level is Associated With Severe SARS-CoV-2 Infection: A Cross-Sectional Observational Study.Biomarker insights · 2022Article
- N-Linked Glycosylation on Anthrax Toxin Receptor 1 Is Essential for Seneca Valley Virus Infection.Viruses · 2021Article
- Study of combining virtual screening and antiviral treatments of the Sars-CoV-2 (Covid-19).Microbial pathogenesis · 2020Review
- COVID-19 and the Kidney: From Epidemiology to Clinical Practice.Journal of clinical medicine · 2020Review
- Host-Virus Arms Races Drive Elevated Adaptive Evolution in Viral Receptors.Journal of virology · 2020Article
- Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses.Biochemical and biophysical research communications · 2020Article
- IILLS: predicting virus-receptor interactions based on similarity and semi-supervised learning.BMC bioinformatics · 2019Article
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
motivationReceptor mediated entry is the first step for viral infection. However, the question of how viruses select receptors remains unanswered.
resultsHere, by manually curating a high-quality database of 268 pairs of mammalian virus-host receptor interaction, which included 128 unique viral species or sub-species and 119 virus receptors, we found the viral receptors are structurally and functionally diverse, yet they had several common features when compared to other cell membrane proteins: more protein domains, higher level of N-glycosylation, higher ratio of self-interaction and more interaction partners, and higher expression in most tissues of the host. This study could deepen our understanding of virus-receptor interaction. AVAILABILITY AND IMPLEMENTATION: The database of mammalian virus-host receptor interaction is available at http://www.computationalbiology.cn: 5000/viralReceptor. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
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