ArticleEuropean heart journal. Cardiovascular Imaging2019
Longitudinal 18F-FDG PET imaging in a rat model of autoimmune myocarditis.
Article in European heart journal. Cardiovascular Imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Persistent Focal MyocardialDiagnostics (Basel, Switzerland) · 2026Article
- Comparing Two Folate Receptor β‑Targeted Tracers in a Rat Model of Experimental Autoimmune Myocarditis.ACS pharmacology & translational science · 2025Article
- Immunometabolism in heart failure.Nature reviews. Cardiology · 2025Review
- Illuminating Cardiac Remodeling: Insights From [Journal of the American Heart Association · 2025Article
- The assessment of left ventricular volume and function in gated small animalEJNMMI research · 2023Article
- Recent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers.International journal of molecular sciences · 2022Review
- Impact of shear wave dispersion slope analysis for assessing the severity of myocarditis.Scientific reports · 2022Article
- Myocardial Dysfunction and Heart Failure in Rheumatoid Arthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2022Review
- Molecular Imaging-Derived Biomarker of Cardiac Nerve Integrity - Introducing High NET Affinity PET ProbeTheranostics · 2022Article
- Molecular imaging of inflammation crosstalk along the cardio-renal axis following acute myocardial infarction.Theranostics · 2021Article
- Emerging F-18-Labelled PET Myocardial Perfusion Tracers.Current cardiology reports · 2020Review
- Nuclear cardiology in the context of multimodality imaging to detect cardiac toxicity from cancer therapeutics: Established and emerging methods.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Review
- Early Detection of Localized Immunity in Experimental Autoimmune Myocarditis Using [Molecular imaging and biology · 2020Article
- Heart failure with preserved ejection fraction: the missing pieces in diagnostic imaging.Heart failure reviews · 2020Review
- Dilated cardiomyopathy.Nature reviews. Disease primers · 2019Review
- Moving into the next era of PET myocardial perfusion imaging: introduction of novelThe international journal of cardiovascular imaging · 2019Review
- Article
- Recent Progress in PET and SPECT Myocardial Perfusion Imaging: From Radiopharmaceuticals to Imaging Innovations.Iranian journal of pharmaceutical research : IJPRReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsAlthough mortality rate is very high, diagnosis of acute myocarditis remains challenging with conventional tests. We aimed to elucidate the potential role of longitudinal 2-Deoxy-2-18F-fluoro-D-glucose (18F-FDG) positron emission tomography (PET) inflammation monitoring in a rat model of experimental autoimmune myocarditis. METHODS AND
resultsAutoimmune myocarditis was induced in Lewis rats by immunizing with porcine cardiac myosin emulsified in complete Freund's adjuvant. Time course of disease was assessed by longitudinal 18F-FDG PET imaging. A correlative analysis between in- and ex vivo18F-FDG signalling and macrophage infiltration using CD68 staining was conducted. Finally, immunohistochemistry analysis of the cell-adhesion markers CD34 and CD44 was performed at different disease stages determined by longitudinal 18F-FDG PET imaging. After immunization, myocarditis rats revealed a temporal increase in 18F-FDG uptake (peaked at week 3), which was followed by a rapid decline thereafter. Localization of CD68 positive cells was well correlated with in vivo18F-FDG PET signalling (R2 = 0.92) as well as with ex vivo18F-FDG autoradiography (R2 = 0.9, P < 0.001, respectively). CD44 positivity was primarily observed at tissue samples obtained at acute phase (i.e. at peak 18F-FDG uptake), while CD34-positive staining areas were predominantly identified in samples harvested at both sub-acute and chronic phases (i.e. at 18F-FDG decrease).
conclusion18F-FDG PET imaging can provide non-invasive serial monitoring of cardiac inflammation in a rat model of acute myocarditis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.