ArticleInternal medicine (Tokyo, Japan)2018
Lambda Light Chain Non-crystalline Proximal Tubulopathy with IgD Lambda Myeloma.
Article in Internal medicine (Tokyo, Japan), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- A case report of biclonal immunoglobulin D lambda/lambda multiple myeloma in patient with liver echinococcosis.Biochemia medica · 2024Article
- Successful autologous stem cell transplantation for light chain proximal tubulopathy with severe kidney injury.Clinical case reports · 2023Article
- IgD lambda multiple myeloma causing hyperammonaemia with possibly reduced ammonium excretion.BMJ case reports · 2022Article
- Light chain proximal tubulopathy with cast nephropathy in monoclonal gammopathy of renal significance.BMJ case reports · 2020Article
- Clinicopathological characteristics of light chain proximal tubulopathy in Korean patients and the diagnostic usefulness of immunohistochemical staining for immunoglobulin light chain.BMC nephrology · 2020Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Light Chain Proximal Tubulopathy (LCPT) is a rare form of paraprotein-related kidney disease in which monoclonal free light chains damage the proximal renal tubular epithelial cells. We herein report the case of a 78-year-old woman who presented with anemia and kidney dysfunction. Serum and urine protein electrophoresis analyses revealed a monoclonal IgD and λ free light chains. Proximal tubular injury and the accumulation of λ light chains were found by kidney biopsy. Electron microscopy revealed no organized structure suggestive of crystals. LCPT was caused by IgD lambda myeloma and bortezomib and dexamethasone therapy led to very good partial response (VGPR) without a worsening of the kidney function.
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