Evidence map›Paper›PMID 30101905›Full record

ArticleInternal medicine (Tokyo, Japan)2018

Reversible Non-parkinsonian Bradykinesia with Impaired Frontal Lobe Function as the Predominant Manifestation of Adrenal Insufficiency.

Nobumasa Ohara, Mayuko Hirokawa, Michi Kobayashi, Yohei Ikeda, Yuichiro Yoneoka, Yasuhiro Seki, Katsuhiko Akiyama, Takashi Tani, Kenshi Terajima, Tetsutaro Ozawa

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PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Nobumasa OharaDepartment of Endocrinology and Metabolism, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan.
Mayuko HirokawaDepartment of Endocrinology and Metabolism, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan.
Michi KobayashiDepartment of Endocrinology and Metabolism, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan.
Yohei IkedaDepartment of Radiology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan.
Yuichiro YoneokaDepartment of Neurosurgery, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan.
Yasuhiro SekiDepartment of Neurosurgery, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan.
Katsuhiko AkiyamaDepartment of Neurosurgery, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan.
Takashi TaniDepartment of Neurology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan.
Kenshi TerajimaDepartment of Neurology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan.
Tetsutaro OzawaDepartment of Neurology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan.
Niigata University Medical and Dental Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 69-year-old Japanese man with a history of suprasellar surgery and irradiation developed bradykinesia and mild fatigue without muscle weakness, myalgia, pyramidal or extrapyramidal signs, parkinsonian symptoms, or ataxia. An endocrinological work-up revealed anterior hypopituitarism associated with secondary adrenal insufficiency. Higher brain function tests indicated an impaired frontal lobe function. The patient's bradykinesia, fatigue, and frontal lobe dysfunction improved within 2 weeks after the initiation of corticosteroid replacement therapy. To our knowledge, this is the first reported case of adrenal insufficiency manifesting as non-parkinsonian bradykinesia. Physicians should consider reversible non-parkinsonian bradykinesia associated with frontal lobe dysfunction as an unusual manifestation of adrenal insufficiency.

Indexed as

Adrenal InsufficiencyAgedFatigueFrontal LobeHumansHypokinesiaHypopituitarismMaleadrenal insufficiencybradykinesiafrontal lobe dysfunctionhydrocortisonehypopituitarismnon-parkinsonian

Identifiers

PMID30101905
PMCPMC6306535
OpenAlexW2887864227

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.