Observational studyNeurologia medico-chirurgica2018
Outcomes after Traumatic Brain Injury with Concomitant Severe Extracranial Injuries.
Observational study in Neurologia medico-chirurgica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Guidelines for Neuroprognostication in Critically Ill Adults with Moderate-Severe Traumatic Brain Injury.Neurocritical care · 2024Pooled it
- Influence of multiple trauma on the effect of transfusion strategies in patients with traumatic brain injury: a sub-study of the HEMOTION trial.Intensive care medicine · 2026Trial
- Association of lifesaving versus non-lifesaving extracranial surgery with long-term outcome after severe traumatic brain injury: a prospective CENTER-TBI cohort analysis.World journal of emergency surgery : WJES · 2026Observational
- Anti-PD-L1 therapy to prevent systemic immune suppression after polytraumatic brain injury in rats.The journal of trauma and acute care surgery · 2026Article
- Factors Associated With Poor One-Month Glasgow Outcome Scale Scores After Traumatic Brain Injury With Intracranial Hemorrhage in Adult Patients Presenting to the Emergency Department.Emergency medicine international · 2026Article
- The normative modelling framework for traumatic brain injury.Brain : a journal of neurology · 2025Review
- Outcomes and prognostic factors in patients with combined severe traumatic brain injury and abdominal trauma: a retrospective observational study.BMC emergency medicine · 2025Observational
- Review
- Article
- Clinical outcomes and safety of percutaneous dilatational tracheostomy in patients with severe traumatic brain injury.American journal of translational research · 2025Article
- Association Between Metabolic and Inflammatory Biomarkers and Prognosis in Traumatic Brain Injury: A Focus on Short- and Medium-Term Mortality.Journal of inflammation research · 2025Article
- The effect of extended early rehabilitation on the treatment outcome of patients with moderate and severe traumatic brain injury.Frontiers in human neuroscience · 2025Article
- Prognostic Factors and Initial Treatment Strategies for Patients with Head Trauma and Vital Signs of Shock.Neurotrauma reports · 2025Article
- Early Thrombocytopenia at Hospital Admission Predicts Mortality in Patients with Non-Isolated Severe Traumatic Brain Injury.Biomedicines · 2024Article
- The association of acute and chronic phase cerebrovascular reactivity with patient reported quality of life following moderate-to-severe traumatic brain injury.Scientific reports · 2024Article
- Early vs Late Fixation of Extremity Fractures Among Adults With Traumatic Brain Injury.JAMA network open · 2024Article
- The Use of Corticosteroid Randomisation after Significant Head Injury (CRASH) Prognostic Model as Mortality Predictor of Traumatic Brain Injury Patients Underwent Surgery in Low-Middle Income Countries.Anesthesiology research and practice · 2024Article
- Intramural Healthcare Consumption and Costs After Traumatic Brain Injury: A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study.Journal of neurotrauma · 2023Observational
- Effectiveness of Administration of Fibrinogen Concentrate as Prevention of Hypofibrinogenemia in Patients with Traumatic Brain Injury with a Higher Risk for Severe Hyperfibrinolysis: Single Center Before-and-After Study.Neurocritical care · 2023Article
- Identifying predictive factors for mortality in patients with TBI at a neurosurgery department.Journal of medicine and life · 2023Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traumatic brain injury (TBI) is a leading cause of death and disability in trauma patients. Patients with TBI frequently sustain concomitant injuries in extracranial regions. The effect of severe extracranial injury (SEI) on the outcome of TBI is controversial. For 8 years, we retrospectively enrolled 485 patients with the blunt head injury with head abbreviated injury scale (AIS) ≧ 3. SEI was defined as AIS ≧ 3 injuries in the face, chest, abdomen, and pelvis/extremities. Vital signs and coagulation parameter values were also extracted from the database. Total patients were dichotomized into isolated TBI (n = 343) and TBI associated with SEI (n = 142). The differences in severity and outcome between these two groups were analyzed. To assess the relation between outcome and any variables showing significant differences in univariate analysis, we included the parameters in univariable and multivariable logistic regression analyses. Mortality was 17.8% in the isolated TBI group and 21.8% in TBI with SEI group (P = 0.38), but the Glasgow Outcome Scale (GOS) in the TBI with SEI group was unfavorable compared to the isolated TBI group (P = 0.002). Patients with SBP ≦ 90 mmHg were frequent in the TBI with SEI group. Adjusting for age, GCS, and length of hospital stay, SEI was a strong prognostic factor for mortality with adjusted ORs of 2.30. Hypotension and coagulopathy caused by SEI are considerable factors underlying the secondary insults to TBI. It is important to manage not only the brain but the whole body in the treatment of TBI patients with SEI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.