ReviewCurrent neuropharmacology2019
Psychopharmacological Treatment of Obsessive-Compulsive Disorder (OCD).
Review in Current neuropharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 2 syntheses or guidelines pooled it, 215 citations in OpenAlex.
- Treatment effectiveness for comorbid anorexia nervosa and obsessive-compulsive disorder: a systematic review.International journal of psychiatry in clinical practice · 2025Pooled it
- Prediction and diagnosis of depression using machine learning with electronic health records data: a systematic review.BMC medical informatics and decision making · 2023Pooled it
- Linking electric field directionality to treatment outcome in OCD: Insights from patient-specific tDCS modeling.Translational psychiatry · 2026Trial
- The Effectiveness of Herbal Mixture of Echium amoenum L. and Rheum ribes on Obsessive-Compulsive Disorder: A Randomized Controlled Triple-Blind Clinical Trial.Neuropsychopharmacology reports · 2025Trial
- Effect of Multivoice Chorus on Interpersonal Communication Disorder.Occupational therapy international · 2022Trial
- Mechanisms of Selective Serotonin Reuptake Inhibitors in Treatment-Resistant Obsessive-Compulsive Disorder: Cortico-Striatal Circuitry, Glutamatergic Dysregulation, and Neuroplastic Constraints.Molecular neurobiology · 2026Review
- Case Report: A Multimodal Treatment Approach Combining Multi-Target rTMS with a Modified, Largely Self-Administered, Clinician-Supervised Exposure and Response Prevention Protocol Using a Verbal Termination Cue in Two Patients with Severe Obsessive-Compulsive Disorder.Journal of clinical medicine · 2026Article
- A fine line between obsessive-compulsive disorder (OCD) and psychotic disorder: a case report.Journal of medical case reports · 2026Article
- Article
- Negative symptomatology and clozapine-induced obsessive-compulsive symptoms: a cross-sectional analysis.European archives of psychiatry and clinical neuroscience · 2026Article
- Review
- A Narrative Review of Augmentation Strategies in Obsessive-Compulsive Disorder: Antipsychotics as Mainstay and Emerging Role of Extended-Release Methylphenidate.Pharmaceuticals (Basel, Switzerland) · 2026Review
- First case of schizophrenia and OCD in TK2-related mitochondrial DNA depletion myopathy: a case report.BMC psychiatry · 2026Article
- Evidence of increased risk of five psychiatric disorders due to antidepressants.European archives of psychiatry and clinical neuroscience · 2026Article
- Treatment of therapy-resistant OCD with application of transcranial alternating current stimulation (tACS): a case series.BMC psychiatry · 2026Article
- Third-Generation Antipsychotics as Augmentation in Treatment-Resistant Obsessive-Compulsive Disorder: A Narrative Review of Efficacy and Tolerability.Biomedicines · 2026Article
- Efficacy and safety profile of vortioxetine as an add-on molecule in obsessive-compulsive disorder: a randomized double-blinded placebo-controlled superiority trial - a study protocol.BMC psychiatry · 2025Article
- Observational
- Article
- Decreased inter- and intra-network connectivity after group cognitive behavioral therapy in patients with unmedicated obsessive-compulsive disorder.World journal of psychiatry · 2025Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObsessive-compulsive disorder (OCD) is associated with affective and cognitive symptoms causing personal distress and reduced global functioning. These have considerable societal costs due to healthcare service utilization.
objectiveOur aim was to assess the efficacy of pharmacological interventions in OCD and clinical guidelines, providing a comprehensive overview of this field.
methodsWe searched the PubMed database for papers dealing with drug treatment of OCD, with a specific focus on clinical guidelines, treatments with antidepressants, antipsychotics, mood stabilizers, off-label medications, and pharmacogenomics.
resultsProlonged administration of selective serotonin reuptake inhibitors (SSRIs) is most effective. Better results can be obtained with a SSRI combined with cognitive behavioral therapy (CBT) or the similarly oriented exposure and response prevention (ERP). Refractory OCD could be treated with different strategies, including a switch to another SSRI or clomipramine, or augmentation with an atypical antipsychotic. The addition of medications other than antipsychotics or intravenous antidepressant administration needs further investigation, as the evidence is inconsistent. Pharmacogenomics and personalization of therapy could reduce treatment resistance.
conclusionsSSRI/clomipramine in combination with CBT/ERP is associated with the optimal response compared to each treatment alone or to other treatments. New strategies for refractory OCD are needed. The role of pharmacogenomics could become preponderant in the coming years.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.