Evidence map›Paper›PMID 30101706›Full record

ArticleCurrent Alzheimer research2018

Probiotic Supplementation in Patients with Alzheimer's Dementia - An Explorative Intervention Study.

Friedrich Leblhuber, Kostja Steiner, Burkhard Schuetz, Dietmar Fuchs, Johanna M Gostner

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current Alzheimer research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed, 6 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

139 citing papers in PubMed, 6 syntheses or guidelines pooled it, 264 citations in OpenAlex.

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79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Friedrich LeblhuberDepartment of Gerontology, Neuromed Campus, Kepler University Clinic, Linz, Austria.
Kostja SteinerDepartment of Gerontology, Neuromed Campus, Kepler University Clinic, Linz, Austria.
Burkhard SchuetzBiovis Diagnostik MVZ GmbH, Limburg, Germany.
Dietmar FuchsDivision of Biological Chemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Johanna M GostnerDivision of Medical Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Innsbruck Medical University · ATKepler Universitätsklinikum · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDysbiosis of intestinal microbiota in the elderly can cause a leaky gut, which may result in silent systemic inflammation and promote neuroinflammation - a relevant pathomechanism in the early course of Alzheimer's disease.

objectiveThe rebalancing of the microbiome could benefically impact on gut inflammation and immune activation.

methodsIn this study, routine laboratory tests in twenty outpatients (9 females, 11 males, aged 76.7 ± 9.6 years) with Alzheimer's disease were investigated. The mean Mini Mental State Examination score was 18.5 ± 7.7. Biomarkers of immune activation - serum neopterin and tryptophan breakdown - as well as gut inflammation markers and microbiota composition in fecal specimens were analyzed in 18 patients before and after probiotic supplementation for 4 weeks.

resultsAfter treatment a decline of fecal zonulin concentrations and an increase in Faecalibacterium prausnitzii compared to baseline were observed. At the same time, serum kynurenine concentrations increased (p <0.05). Delta values (before - after) of neopterin and the kynurenine to tryptophan ratios (Kyn/Trp) correlated significantly (p <0.05).

conclusionResults show that the supplementation of Alzheimer's disease patients with a multispecies probiotic influences gut bacteria composition as well as tryptophan metabolism in serum. The correlation between Kyn/Trp and neopterin concentrations points to the activation of macrophages and/or dendritic cells. Further studies are warranted to dissect the potential consequences of Probiotic supplementation in the course of Alzheimer's disease.

Indexed as

Dietary SupplementsAgedAged, 80 and overAlzheimer DiseaseCholera ToxinFecesFemaleGastrointestinal MicrobiomeHaptoglobinsHumansMaleMental Status ScheduleMiddle AgedProbioticsProtein PrecursorsCholera ToxinHaptoglobinsProtein PrecursorszonulinAlzheimer`s diseasebrain-gut axisdementiaFaecalibacterium prausnitziiGut microbiotaneopterinneuroinflammationprobiotics.

Identifiers

PMID30101706
PMCPMC6340155
OpenAlexW2886952520

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.