Evidence map›Paper›PMID 30101436›Full record

ArticleJournal of clinical laboratory analysis2019

Study on the levels of glycosylated lipoprotein in patients with coronary artery atherosclerosis.

Wei Luo, Yong He, Fei Ding, Xin Nie, Xiao-Ling Li, Hao-Lan Song, Gui-Xing Li

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
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Article in Journal of clinical laboratory analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Wei LuoDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.ORCID http://orcid.org/0000-0002-9632-6683
Yong HeDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Fei DingDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Xin NieDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Xiao-Ling LiDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Hao-Lan SongDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Gui-Xing LiDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Sichuan University · CN

Funding

Sichuan provinice Science and Technology Department 2016SZ0044
6 · The paper itself

Abstract

backgroundThe main risk factors for atherosclerosis patients are not fully explicated. The aim of this study was to analyze the levels of blood lipid and glycosylated lipoprotein in patients with coronary artery atherosclerosis and healthy individuals and to study the relationship between the glycosylated lipoprotein and atherosclerosis.

methodsThe study involved 200 patients diagnosed with myocardial infarction caused by coronary atherosclerosis as case group and 230 healthy individuals as control group. We analyzed and contrasted the levels of blood lipid and glycosylated lipoprotein between the different groups. In addition, we investigated the correlation between glycosylated low-density lipoprotein (G-LDL) and glucose levels.

resultsThere is no statistical difference between the level of TG in case group and control group. The level of CHOL, HDL-C, and LDL-C in case group is significantly lower than that in control group (3.90 [3.23, 4.42] vs 5.16 [4.86, 5.77] [mmol/L]; 1.09 [0.83, 1.38] vs 1.46 [1.15, 1.80] [mmol/L]; 2.22 [1.68, 2.81] vs 2.95 [2.60, 3.27] [mmol/L]) (P < 0.05). The level of GLU, HbA1c, G-HDL, and G-LDL in case group is significantly higher than that in control group (7.10 [5.68, 9.27] vs 4.84 [4.68, 5.07] [mmol/L]; 6.8 [6.3, 7.4] vs 5.9 [5.6, 6.1] [%]; 30.08 [25.04, 40.17] vs 22.95 [18.14, 27.06] [ng/mL], 6.26 [4.95, 7.50] vs 3.61 [2.66, 5.15] [ng/mL]) (p < 0.05). The level of G-LDL in patients with coronary atherosclerosis was relevant with the level of GLU and HbA1c (r = 0.625, 0.706, P < 0.05), and there was no relevance with LDL-C (r = 0.331, P > 0.05).

conclusionHyperlipidemia is not an important cause of coronary atherosclerosis. High glucose levels and glycosylated lipoprotein are of high importance in the development and progression of coronary atherosclerosis.

Indexed as

AgedAtherosclerosisBlood GlucoseCase-Control StudiesCoronary Artery DiseaseFemaleGlycated ProteinsGlycation End Products, AdvancedHumansLipoproteins, HDLLipoproteins, LDLMaleMiddle AgedMyocardial InfarctionBlood Glucoseglycated lipoproteins, HDLglycated lipoproteins, LDLGlycated ProteinsGlycation End Products, AdvancedLipoproteins, HDLLipoproteins, LDLcoronary atherosclerosisglycosylated lipoproteinmyocardial infarction

Identifiers

PMID30101436
PMCPMC6430348
OpenAlexW2886549878

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.