← GLP-1 receptor agonists × adverse events & safety

SynthesisEndocrine2018

The safety and efficacy of once-weekly glucagon-like peptide-1 receptor agonist semaglutide in patients with type 2 diabetes mellitus: a systemic review and meta-analysis.

Xuejing Li et al.PubMed ↗Publisher ↗

What the trial testedrandomised · 9,519 people · 2018

Randomised comparison

Raised glycemic control

2.3×1.9× to 2.7×

Bigger than 6 in 10 for glycemic control

As reported

RR 2.26, 95% CI 1.89–2.70

Randomised comparison

Raised adverse events & safety

+6%+2% to +11%

Bigger than 2 in 10 for adverse events & safety

As reported

RR 1.06, 95% CI 1.02–1.11

Range includes no effect

No clear effect on adverse events & safety

−6%−14% to +2%

Bigger than 2 in 10 for adverse events & safety

As reported

RR 0.94, 95% CI 0.86–1.02

Range includes no effect

No clear effect on glycemic control

−7%−26% to +16%

Smaller than almost all for glycemic control

As reported

RR 0.93, 95% CI 0.74–1.16

Four numbers in the abstract

the abstract, start to end

… who achieved HbA1c < 7.0% [RR 2.26, 95% CI (1.89, 2.70), …

… incidence of adverse events (AEs) [RR 1.06, 95% CI (1.02, 1.11), p < 0.0001] and an analogous incidence in serious adverse events (SAEs) [RR 0.94, 95% CI (0.86, 1.02), p = 0.11] and hypoglycaemic events (severe or blood glucose (BG)-confirmed symptomatic) [RR 0.93, 95% CI (0.74, 1.16), p = 0.50] …

← favours treatmentfavours comparator →
could be chance
Glycemic control
RR 2.261.89–2.70
Adverse events & safety
RR 1.061.02–1.11
Adverse events & safety
RR 0.940.86–1.02
Glycemic control
RR 0.930.74–1.16
GLP-1 receptor agonistsGlycemic controlAdverse events & safety

GLP-1 receptor agonists × adverse events & safetyharms?mixed

unlikelylikely
0.00not counted

GLP-1 receptor agonists × glycemic controlhelps?replicated

unlikelylikely
0.90not counted
← favours treatmentfavours comparator →
more certainless certain
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Full record →Abstract, authors, funding and every citing paper · PMID 30101378