Evidence map›Paper›PMID 30101028›Full record

ArticleMolecular and clinical oncology2018

Malignant potential of epithelioid angiomyolipomas of the liver: A case report and comprehensive review of the literature.

Zoe Garoufalia, Nikolaos Machairas, Ioannis D Kostakis, Aliki Liakea, Petros Tsaparas, George Liapis, Georgios C Sotiropoulos

Open access · diamondAbstract read
In one paragraph

Article in Molecular and clinical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Zoe GaroufaliaSecond Department of Propaedeutic Surgery, Laiko General Hospital, 11527 Athens, Greece.
Nikolaos MachairasSecond Department of Propaedeutic Surgery, Laiko General Hospital, 11527 Athens, Greece.
Ioannis D KostakisSecond Department of Propaedeutic Surgery, Laiko General Hospital, 11527 Athens, Greece.
Aliki LiakeaFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Petros TsaparasSecond Department of Propaedeutic Surgery, Laiko General Hospital, 11527 Athens, Greece.
George LiapisFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Georgios C SotiropoulosSecond Department of Propaedeutic Surgery, Laiko General Hospital, 11527 Athens, Greece.
Laiko General Hospital of Athens · GRNational and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatic epithelioid angiomyolipoma (HEAML) is a rare mesenchymal tumor that has been reported to have malignant potential. We herein describe a rare case of atypical HEAML. A 43-year-old Caucasian male patient visited his general practitioner due to a productive cough persisting for >2 months. During evaluation with several imaging tests, a chest computed tomography (CT) incidentally revealed a well-demarcated lesion in the caudate lobe of the liver, sized 7 cm. An abdominal magnetic resonance imaging examination confirmed the findings of the CT. The possibility of hepatocellular carcinoma at that time could not be excluded. Due to inconclusive cross-sectional imaging, the patient underwent left hepatectomy with additional resection of segment I. The patient's postoperative course was uneventful. A diagnosis of 'atypical' HEAML was established in the present case. The majority of HEAMLs are considered to be benign, although there are several reported cases exhibiting malignant behavior, such as tumor growth, presence of atypical cells, recurrence after surgical resection, metastasis and invasive growth into the liver parenchyma and alongside the vessels. From 2000 onwards, 19 cases of malignant hepatic AML have been reported. Malignant transformation is considered to occur mostly in the epithelioid subtype. To that end, when epithelioid or atypical characteristics are identified on preoperative biopsy, resection is indicated due to the high probability of malignancy.

Indexed as

angiomyolipomaatypicalepithelioidliverresection

Identifiers

PMID30101028
PMCPMC6083421
OpenAlexW2808172295

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.