Evidence map›Paper›PMID 30100902›Full record

ArticleFrontiers in immunology2018

Innate Immunity Induced by the Major Allergen Alt a 1 From the Fungus

Tristan Hayes, Amanda Rumore, Brad Howard, Xin He, Mengyao Luo, Sabina Wuenschmann, Martin Chapman, Shiv Kale, Liwu Li, Hirohito Kita and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Allergen-induced DNA release by the airway epithelium amplifies type 2 immunity.The Journal of allergy and clinical immunology · 2023
    Article
  7. Article
  8. Morphological and Molecular Characterization of SomePlants (Basel, Switzerland) · 2022
    Article
  9. Alt a 1 Promotes Allergic AsthmaFrontiers in immunology · 2022
    Article
  10. Article
  11. Journal of fungi (Basel, Switzerland) · 2021
    Review
  12. Article
  13. Mechanisms forFrontiers in allergy · 2021
    Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Tristan HayesDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA, United States.
Amanda RumoreDepartment of Biology, Randolph College, Lynchburg, VA, United States.
Brad HowardDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA, United States.
Xin HeDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA, United States.
Mengyao LuoDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA, United States.
Sabina WuenschmannIndoor Biotechnologies, Charlottesville, VA, United States.
Martin ChapmanIndoor Biotechnologies, Charlottesville, VA, United States.
Shiv KaleBiocomplexity Institute, Virginia Tech, Blacksburg, VA, United States.
Liwu LiDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA, United States.
Hirohito KitaDivision of Allergic Diseases, Internal Medicine, Mayo Clinic, Rochester, MN, United States.
Christopher B LawrenceDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA, United States.
Virginia Tech · USIndoor Biotechnologies (United States) · USRandolph College · USWinnMed · US

Funding

VT Initiative for Maximizing Student DiversityR25GM072767 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SMITH, EDWARD J · 2007 to 2021
$6.9M
Mechanisms of IL-33 secretion in allergic diseasesR01AI128729 · NIAID · MAYO CLINIC ROCHESTER · PI Hirohito Kita, SCOTT M. O'GRADY · 2017 to 2026
$5.6M
Alternaria and ribonucleases in Th2-type immunityR01AI071106 · NIAID · MAYO CLINIC ROCHESTER · PI KITA, HIROHITO · 2008 to 2017
$4.0M
The Role of the Major Alternaria Allergen Alt_a_1 in Airway InflammationR21AI094071 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI LAWRENCE, CHRISTOPHER BRIAN, TYLER, BRETT MERRICK · 2011 to 2012
$429k
Novel Innate Receptor for the Fungal PAMP chitinR21AI115986 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI LAWRENCE, CHRISTOPHER BRIAN, LI, LIWU · 2015 to 2016
$427k
NIAID NIH HHS R01 AI071106NIAID NIH HHS R01 AI128729NIAID NIH HHS R21 AI094071NIAID NIH HHS R21 AI115986NIGMS NIH HHS R25 GM072767
6 · The paper itself

Abstract

Allergens are molecules that elicit a hypersensitive inflammatory response in sensitized individuals and are derived from a variety of sources. Alt a 1 is the most clinically important secreted allergen of the ubiquitous fungus,

Indexed as

Immunity, InnateRhinitis, AllergicAllergensAlternariaAlveolar Epithelial CellsAntigens, FungalCells, CulturedChemokinesHumansRespiratory HypersensitivityToll-Like ReceptorsAllergensALTB1 protein, Alternaria brassicicolaAntigens, FungalChemokinesToll-Like ReceptorsallergenAlternariafungus–host interactioninnate immunitymoldtoll-like receptors

Identifiers

PMID30100902
PMCPMC6072870
OpenAlexW2884692287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.