Evidence map›Paper›PMID 30100759›Full record

ArticleClinical epidemiology2018

Association of obesity, diabetes and hypertension with cognitive impairment in older age.

Insa Feinkohl, Gunnar Lachmann, Wolf-Rüdiger Brockhaus, Friedrich Borchers, Sophie K Piper, Thomas H Ottens, Hendrik M Nathoe, Anne-Mette Sauer, Jan M Dieleman, Finn M Radtke and 3 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05732935 (Fasting to Provide Energy Needed to Help Adults in Need of Cognitive Enhancement), which is not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05732935 nacompletednot on this mapstarted 2023, after this paper: background citation

Fasting to Provide Energy Needed to Help Adults in Need of Cognitive Enhancement (FASTING ENHANCE)

TypeinterventionalSponsorUniversity of FloridaRan2023 to 2026Enrolled45ConditionsOverweight and Obesity, Time Restricted Feeding, Alzheimer DiseaseArmsTime Restricted Eating intervention, Successful Aging Comparison Group (LEARN)
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Insa Feinkohl *Molecular Epidemiology Research Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin-Buch, Germany, insa.feinkohl@mdc-berlin.de.
Gunnar Lachmann *Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Wolf-Rüdiger BrockhausDepartment of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Friedrich BorchersDepartment of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Sophie K PiperInstitute of Biometry and Clinical Epidemiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Thomas H OttensDepartment of Anesthesiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Hendrik M NathoeDepartment of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Anne-Mette SauerDepartment of Anesthesiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Jan M DielemanDepartment of Anesthesiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Finn M RadtkeDepartment of Anesthesiology, Naestved Hospital, Naestved, Denmark.
Diederik van DijkDepartment of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
Tobias Pischon *Molecular Epidemiology Research Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin-Buch, Germany, insa.feinkohl@mdc-berlin.de.
Claudia Spies *Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Humboldt-Universität zu Berlin · DEUniversity Medical Center Utrecht · NLMax Delbrück Center · DENæstved Sygehus · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAge-related cognitive impairment is rising in prevalence but is not yet fully characterized in terms of its epidemiology. Here, we aimed to elucidate the role of obesity, diabetes and hypertension as candidate risk factors.

methodsOriginal baseline data from 3 studies (OCTOPUS, DECS, SuDoCo) were obtained for secondary analysis of cross-sectional associations of diabetes, hypertension, blood pressure, obesity (body mass index [BMI] ≥30 kg/m

resultsAnalyses totaled 1545 participants with a mean age of 61 years (OCTOPUS) to 70 years (SuDoCo). Cognitive impairment was found in 29.0% of participants in DECS, 8.2% in SuDoCo and 45.6% in OCTOPUS. In pooled analyses, after adjustment for age, sex, diabetes and hypertension, obesity was associated with a 1.29-fold increased prevalence of cognitive impairment (risk ratio [RR] 1.29; 95% CI 0.98, 1.72). Each 1 kg/m

conclusionOur results show that older people who are obese have higher prevalence of cognitive impairment compared with normal weight and overweight individuals, and independently of co-morbid hypertension or diabetes. Prospective studies are needed to investigate the temporal relationship of the association.

Indexed as

agingbody mass indexcognitive epidemiologycognitive impairmentdiabeteshypertensionobesity

Identifiers

PMID30100759
PMCPMC6064155
OpenAlexW2883459317

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.