Evidence map›Paper›PMID 30100717›Full record

ArticleInternational journal of chronic obstructive pulmonary disease2018

The use of a standardized order set reduces systemic corticosteroid dose and length of stay for individuals hospitalized with acute exacerbations of COPD: a cohort study.

Swati Gulati, Aline N Zouk, Jonathan P Kalehoff, Christopher S Wren, Peter N Davison, Denay Porter Kirkpatrick, Surya P Bhatt, Mark T Dransfield, James Michael Wells

Open access · goldAbstract read
In one paragraph

Article in International journal of chronic obstructive pulmonary disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Implementing acute exacerbations of COPD care bundles: evidence, effectiveness and future directions.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Swati GulatiDepartment of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA, jmwells@uabmc.edu.
Aline N ZoukDepartment of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA, jmwells@uabmc.edu.
Jonathan P KalehoffDivision of Internal Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
Christopher S WrenHarrison School of Pharmacy, Auburn University, Auburn, AL, USA.
Peter N DavisonUniversity of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Denay Porter KirkpatrickDepartment of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA, jmwells@uabmc.edu.
Surya P BhattDepartment of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA, jmwells@uabmc.edu.
Mark T DransfieldDepartment of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA, jmwells@uabmc.edu.
James Michael WellsDepartment of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA, jmwells@uabmc.edu.
University of Alabama at Birmingham Hospital · USUniversity of Alabama at Birmingham · USAuburn University · US

Funding

UAB Center for Clinical and Translational Science (CCTS)UL1TR001417 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2015 to 2018
$31.4M
UAB Center for Clinical and Translational Sciences (CCTS)TL1TR001418 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAAG, KENNETH G · 2015 to 2018
$2.1M
Diastolic Dysfunction and Pauci-inflammatory Acute Exacerbations of Chronic Obstructive Pulmonary DiseaseK23HL133438 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BHATT, SURYA P. · 2016 to 2020
$921k
The Role of PGP in COPD-associated Pulmonary HypertensionK08HL123940 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WELLS, JAMES MICHAEL · 2014 to 2018
$744k
UAB Mentoring Program in COPD Patient Oriented ResearchK24HL140108 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DRANSFIELD, MARK T · 2018 to 2022
$439k
NCATS NIH HHS TL1 TR001418NCATS NIH HHS UL1 TR001417NHLBI NIH HHS K08 HL123940NHLBI NIH HHS K23 HL133438NHLBI NIH HHS K24 HL140108
6 · The paper itself

Abstract

Background: Systemic corticosteroids (SC) are an integral part of managing acute exacerbations of COPD (AECOPD). However, the optimal dose and duration vary widely in clinical practice. We hypothesized that the use of a "PowerPlan" order set in the electronic health system (EHS) that includes a 5-day SC order would be associated with a reduced steroid dose and length of stay (LOS) for individuals hospitalized with AECOPD. Patients and methods: We conducted a retrospective cohort study of Medicare recipients discharged with an AECOPD diagnosis from our University Hospital from 2014 to 2016. Our EHS-based "COPD PowerPlan" order set included admission, laboratory, pharmacy, and radiology orders for managing AECOPD. The default SC option included intravenous methyl-prednisolone for 24 hours followed by oral prednisone for 4 days. The primary endpoint was the difference in cumulative steroid dose between the PowerPlan and the usual care group. Secondary endpoints included hospital LOS and readmission rates. Results: The 250 patients included for analysis were 62±11 years old, 58% male, with an FEV Conclusion: Use of a standardized EHS-based order set to manage AECOPD was associated with a reduction in steroid dose and hospital LOS.

Indexed as

Disease ProgressionAgedElectronic Health RecordsFemaleGlucocorticoidsHospitalizationHumansLength of StayMaleMedicareMethylprednisoloneMiddle AgedPrednisonePulmonary Disease, Chronic ObstructiveRetrospective StudiesSteroidsGlucocorticoidsMethylprednisolonePrednisoneSteroidsCOPD exacerbationcorticosteroidelectronic order settreatment

Identifiers

PMID30100717
PMCPMC6067788
OpenAlexW2884031335

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.